ArticlePloS one2014
Intracellular gold nanoparticles increase neuronal excitability and aggravate seizure activity in the mouse brain.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
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- Tau- and α-synuclein-targeted gold nanoparticles: applications, opportunities, and future outlooks in the diagnosis and therapy of neurodegenerative diseases.Journal of nanobiotechnology · 2024Review
- Neuronal maturation-dependent nano-neuro interaction and modulation.Nanoscale horizons · 2023Article
- Investigation of effects of transferrin-conjugated gold nanoparticles on hippocampal neuronal activity and anxiety behavior in mice.Molecular and cellular biochemistry · 2023Article
- Manipulation of New Fluorescent Magnetic Nanoparticles with an Electromagnetic Needle, Allowed Determining the Viscosity of the Cytoplasm of M-HeLa Cells.Pharmaceuticals (Basel, Switzerland) · 2023Article
- A Historical Review of Brain Drug Delivery.Pharmaceutics · 2022Review
- Injectable Nanocomposite Implants Reduce ROS Accumulation and Improve Heart Function after Infarction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Electrophysiological effects of polyethylene glycol modified gold nanoparticles on mouse hippocampal neurons.Heliyon · 2020Article
- Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery.Particle and fibre toxicology · 2019Article
- Intracisternal delivery of PEG-coated gold nanoparticles results in high brain penetrance and long-lasting stability.Journal of nanobiotechnology · 2019Article
- Inhibitory effect of ultrasonic stimulation on the voltage-dependent potassium currents in rat hippocampal CA1 neurons.BMC neuroscience · 2019Article
- Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro.International journal of nanomedicine · 2019Article
- SiOScientific reports · 2018Article
- Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Charge.ACS nano · 2017Article
- Evaluation of multiwalled carbon nanotube cytotoxicity in cultures of human brain microvascular endothelial cells grown on plastic or basement membrane.Toxicology in vitro : an international journal published in association with BIBRA · 2017Article
- Current Status and Future Direction of Nanomedicine: Focus on Advanced Biological and Medical Applications.Nuclear medicine and molecular imaging · 2017Review
- Gold Nanoparticles for Modulating Neuronal Behavior.Nanomaterials (Basel, Switzerland) · 2017Review
- The effect of iron nanoparticles on performance of cognitive tasks in rats.Environmental science and pollution research international · 2017Article
- Pharmacological Tools to Activate Microglia and their Possible use to Study Neural Network Patho-physiology.Current neuropharmacology · 2017Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to their inert property, gold nanoparticles (AuNPs) have drawn considerable attention; their biological application has recently expanded to include nanomedicine and neuroscience. However, the effect of AuNPs on the bioelectrical properties of a single neuron remains unknown. Here we present the effect of AuNPs on a single neuron under physiological and pathological conditions in vitro. AuNPs were intracellularly applied to hippocampal CA1 neurons from the mouse brain. The electrophysiological property of CA1 neurons treated with 5- or 40-nm AuNPs was assessed using the whole-cell patch-clamp technique. Intracellular application of AuNPs increased both the number of action potentials (APs) and input resistance. The threshold and duration of APs and the after hyperpolarization (AHP) were decreased by the intracellular AuNPs. In addition, intracellular AuNPs elicited paroxysmal depolarizing shift-like firing patterns during sustained repetitive firings (SRF) induced by prolonged depolarization (10 sec). Furthermore, low Mg2+-induced epileptiform activity was aggravated by the intracellular AuNPs. In this study, we demonstrated that intracellular AuNPs alter the intrinsic properties of neurons toward increasing their excitability, and may have deleterious effects on neurons under pathological conditions, such as seizure. These results provide some considerable direction on application of AuNPs into central nervous system (CNS).
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