ArticleThe Journal of infectious diseases2014
A role for the vacuolating cytotoxin, VacA, in colonization and Helicobacter pylori-induced metaplasia in the stomach.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 85 citations in OpenAlex.
- Article
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- Article
- Vacuolating Cytotoxin A (VacA) and Extracellular Vesicles inIranian journal of pathology · 2025Review
- Characterization ofThe Pan African medical journal · 2024Article
- There Are No Insurmountable Barriers: Passage of theMembranes · 2023Review
- Helicobacter pylori-activated fibroblasts as a silent partner in gastric cancer development.Cancer metastasis reviews · 2023Review
- Reactive Oxygen Species andAntioxidants (Basel, Switzerland) · 2023Review
- Outer Membrane Vesicles (OMVs) as Biomedical Tools and Their Relevance as Immune-Modulating Agents againstInternational journal of molecular sciences · 2023Review
- Potential Non-invasive Biomarkers of Helicobacter pylori-Associated Gastric Cancer.Journal of gastrointestinal cancer · 2022Review
- The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa.The Journal of pathology · 2022Article
- Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Review
- Virulence Genes ofCanadian journal of gastroenterology & hepatology · 2022Article
- Effects ofMicroorganisms · 2021Article
- Association ofCanadian journal of gastroenterology & hepatology · 2021Review
- Helicobacter pylori-related risk predictors of gastric cancer: The latest models, challenges, and future prospects.Cancer medicine · 2020Review
- Risk factors associated with gastric malignancy during chronicMedical research archives · 2020Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Carriage of Helicobacter pylori strains producing more active (s1/i1) forms of VacA is strongly associated with gastric adenocarcinoma. To our knowledge, we are the first to determine effects of different polymorphic forms of VacA on inflammation and metaplasia in the mouse stomach. Bacteria producing the less active s2/i2 form of VacA colonized mice more efficiently than mutants null for VacA or producing more active forms of it, providing the first evidence of a positive role for the minimally active s2/i2 toxin. Strains producing more active toxin forms induced more severe and extensive metaplasia and inflammation in the mouse stomach than strains producing weakly active (s2/i2) toxin. We also examined the association in humans, controlling for cagPAI status. In human gastric biopsy specimens, the vacA i1 allele was strongly associated with precancerous intestinal metaplasia, with almost complete absence of intestinal metaplasia in subjects infected with i2-type strains, even in a vacA s1, cagA(+) background.
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