ArticlePLoS neglected tropical diseases2014
Dengue virus type 2 (DENV2)-induced oxidative responses in monocytes from glucose-6-phosphate dehydrogenase (G6PD)-deficient and G6PD normal subjects.
Article in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis.Colombia medica (Cali, Colombia) · 2015Pooled it
- Disruption of cellular calcium homeostasis by duck Tembusu virus facilitates viral replication via AMPK pathway activation.Frontiers in cellular and infection microbiology · 2026Article
- Cellular Biology: Virus-Host Interactions and RNA Structure and Function.Current topics in microbiology and immunology · 2026Review
- Spectrum of glucose-6-phosphate dehydrogenase (G6PD) mutations and trends in hemoglobin levels among adult dengue patients in Thailand.PloS one · 2025Article
- Metabolomic landscape of macrophage discloses an anabolic signature of dengue virus infection and antibody-dependent enhancement of viral infection.PLoS neglected tropical diseases · 2024Article
- The global role of G6PD in infection and immunity.Frontiers in immunology · 2024Review
- CMPK2 restricts Zika virus replication by inhibiting viral translation.PLoS pathogens · 2023Article
- Maternal Immune Response to ZIKV Triggers High-Inflammatory Profile in Congenital Zika Syndrome.Viruses · 2023Article
- Abnormal glucose metabolism in virus associated sepsis.Frontiers in cellular and infection microbiology · 2023Review
- Blood glucose promotes dengue virus infection in the mosquito Aedes aegypti.Parasites & vectors · 2021Article
- Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication.Journal of virology · 2020Article
- Review
- Review
- Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children.PloS one · 2019Observational
- A Study on Gene Expression Profile of Endogenous Antioxidant Enzymes: CAT, MnSOD and GPx in Dengue Patients.Indian journal of clinical biochemistry : IJCB · 2017Article
- Human heme oxygenase 1 is a potential host cell factor against dengue virus replication.Scientific reports · 2016Article
- Role of nitric oxide in immune responses against viruses: beyond microbicidal activity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Review
- Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells.PLoS pathogens · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue virus is endemic in peninsular Malaysia. The clinical manifestations vary depending on the incubation period of the virus as well as the immunity of the patients. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent in Malaysia where the incidence is 3.2%. It has been noted that some G6PD-deficient individuals suffer from more severe clinical presentation of dengue infection. In this study, we aim to investigate the oxidative responses of DENV2-infected monocytes from G6PD-deficient individuals. METHODOLOGY: Monocytes from G6PD-deficient individuals were infected with DENV2 and infection rate, levels of oxidative species, nitric oxide (NO), superoxide anions (O2-), and oxidative stress were determined and compared with normal controls. PRINCIPAL
findingsMonocytes from G6PD-deficient individuals exhibited significantly higher infection rates compared to normal controls. In an effort to explain the reason for this enhanced susceptibility, we investigated the production of NO and O2- in the monocytes of individuals with G6PD deficiency compared with normal controls. We found that levels of NO and O2- were significantly lower in the DENV-infected monocytes from G6PD-deficient individuals compared with normal controls. Furthermore, the overall oxidative stress in DENV-infected monocytes from G6PD-deficient individuals was significantly higher when compared to normal controls. Correlation studies between DENV-infected cells and oxidative state of monocytes further confirmed these findings. CONCLUSIONS/SIGNIFICANCE: Altered redox state of DENV-infected monocytes from G6PD-deficient individuals appears to augment viral replication in these cells. DENV-infected G6PD-deficient individuals may contain higher viral titers, which may be significant in enhanced virus transmission. Furthermore, granulocyte dysfunction and higher viral loads in G6PD-deificient individuals may result in severe form of dengue infection.
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