Evidence map›Paper›PMID 24625161›Full record

ArticleAmerican journal of public health2014

Life-course accumulation of neighborhood disadvantage and allostatic load: empirical integration of three social determinants of health frameworks.

Per E Gustafsson, Miguel San Sebastian, Urban Janlert, Töres Theorell, Hugo Westerlund, Anne Hammarström

Abstract read
In one paragraph

Article in American journal of public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Life Course Assessment of Area-Based Social Disadvantage: A Systematic Review.International journal of environmental research and public health · 2023
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  9. The Intersection of Socioeconomic and Environmental Factors in Aging: Insights from a Narrative Review.International journal of environmental research and public health · 2025
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  13. Allostatic Load, Morbidity, and Mortality Among Older Adults: A Multi-Wave Analysis From the National Health and Aging Trends Study.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Per E GustafssonPer E. Gustafsson and Anne Hammarström are with the Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden. Miguel San Sebastian and Urban Janlert are with the Departments of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University. Töres Theorell and Hugo Westerlund are with the Stress Research Institute, Stockholm University, Stockholm, Sweden.
Miguel San Sebastian
Urban Janlert
Töres Theorell
Hugo Westerlund
Anne Hammarström

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe examined if the accumulation of neighborhood disadvantages from adolescence to mid-adulthood were related to allostatic load, a measure of cumulative biological risk, in mid-adulthood, and explored whether this association was similar in women and men.

methodsData were from the participants in the Northern Swedish Cohort (analytical n = 818) at ages 16, 21, 30, and 43 years in 1981, 1986, 1995, and 2008. Personal living conditions were self-reported at each wave. At age 43 years, 12 biological markers were measured to operationalize allostatic load. Registered data for all residents in the cohort participants' neighborhoods at each wave were used to construct a cumulative measure of neighborhood disadvantage. Associations were examined in ordinary least-squares regression models.

resultsWe found that cumulative neighborhood disadvantage between ages 16 and 43 years was related to higher allostatic load at age 43 years after adjusting for personal living conditions in the total sample (B = 0.11; P = .004) and in men (B = 0.16; P = .004), but not in women (B = 0.07; P = .248).

conclusionsOur findings suggested that neighborhood disadvantage acted cumulatively over the life course on biological wear and tear, and exemplified the gains of integrating social determinants of health frameworks.

Indexed as

AdolescentAdultBiomarkersFemaleHealth Status DisparitiesHumansLongitudinal StudiesMalePovertyResidence CharacteristicsSocial Determinants of HealthSocioeconomic FactorsSwedenYoung AdultBiomarkers

Identifiers

PMID24625161
PMCPMC3987591

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.