ArticleLangmuir : the ACS journal of surfaces and colloids2014
Hierarchical hydrodynamic flow confinement: efficient use and retrieval of chemicals for microscale chemistry on surfaces.
Article in Langmuir : the ACS journal of surfaces and colloids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Lab on an end: Micromanipulation using the acoustohydrodynamic pillar array as an end effector.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A paintbrush for delivery of nanoparticles and molecules to live cells with precise spatiotemporal control.Nature methods · 2024Article
- Pixel-based open-space microfluidics for versatile surface processing.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Patterning Biological Gels for 3D Cell Culture inside Microfluidic Devices by Local Surface Modification through Laminar Flow Patterning.Micromachines · 2020Article
- Spatially multiplexed RNA in situ hybridization to reveal tumor heterogeneity.Nucleic acids research · 2020Article
- Microfluidic multipoles theory and applications.Nature communications · 2019Article
- Chemical operations on a living single cell by open microfluidics for wound repair studies and organelle transport analysis.Chemical science · 2019Article
- Rapid micro fluorescenceBiomicrofluidics · 2018Article
- Centimeter-Scale Surface Interactions Using Hydrodynamic Flow Confinements.Langmuir : the ACS journal of surfaces and colloids · 2016Article
- Rapid Subtractive Patterning of Live Cell Layers with a Microfluidic Probe.Journal of visualized experiments : JoVE · 2016Article
- Selective local lysis and sampling of live cells for nucleic acid analysis using a microfluidic probe.Scientific reports · 2016Article
- Micro fluorescence in situ hybridization (μFISH) for spatially multiplexed analysis of a cell monolayer.Biomedical microdevices · 2016Article
- Convection-Enhanced Biopatterning with Recirculation of Hydrodynamically Confined Nanoliter Volumes of Reagents.Analytical chemistry · 2016Article
- A neutrophil treadmill to decouple spatial and temporal signals during chemotaxis.Lab on a chip · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We devised, implemented, and tested a new concept for efficient local surface chemistry that we call hierarchical hydrodynamic flow confinement (hierarchical HFC). This concept leverages the hydrodynamic shaping of multiple layers of liquid to address challenges inherent to microscale surface chemistry, such as minimal dilution, economical consumption of reagent, and fast liquid switching. We illustrate two modes of hierarchical HFC, nested and pinched, by locally denaturing and recovering a 26 bp DNA with as little as 2% dilution and by efficiently patterning an antibody on a surface, with a 5 μm resolution and a 100-fold decrease of reagent consumption compared to microcontact printing. In addition, valveless switching between nanoliter volumes of liquids was achieved within 20 ms. We believe hierarchical HFC will have broad utility for chemistry on surfaces at the microscale.
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