SynthesisBMC infectious diseases2014
Oral antibiotic therapy for the treatment of infective endocarditis: a systematic review.
Synthesis in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04544306 (Partial Oral Antimicrobial Versus Intravenous Antimicrobial Therapy to Treat Infective Endocarditis in People Who Inject Drugs), which is not on this map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Partial Oral Antimicrobial Versus Intravenous Antimicrobial Therapy to Treat Infective Endocarditis in People Who Inject Drugs
Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Partial Oral Antibiotic Therapy for Infective Endocarditis: A Practical Review of Current Evidence and Guidelines.Pathogens (Basel, Switzerland) · 2026Review
- Optimizing intravenous amoxicillin for outpatient parenteral antimicrobial therapy.JAC-antimicrobial resistance · 2026Article
- Outcomes of a Program to Support Outpatient Antibiotic Adherence Among People Experiencing Housing Instability With Serious Injection Drug-Related Infections in Boston, MA: A Propensity Score Matched Study.Open forum infectious diseases · 2026Article
- Tricuspid valve endocarditis in people who inject drugs: strategies to reduce mortality and recurrent infection.Annals of cardiothoracic surgery · 2026Review
- Oritavancin in Complicated Bloodstream Infections and Endocarditis in Spain and Italy (ORIBAC Study): A Retrospective Multicenter Observational Study.Infectious diseases and therapy · 2026Article
- Oral Therapy for Infective Endocarditis: Where Do We Stand?Pathogens (Basel, Switzerland) · 2025Review
- Mapping Review of the Correlations Between Periodontitis, Dental Caries, and Endocarditis.Dentistry journal · 2025Review
- Partial oral versus full intravenous antibiotic treatment of endocarditis in people who inject drugs: A systematic review.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024Article
- Article
- Infective Endocarditis: Still More Challenges Than Convictions.Arquivos brasileiros de cardiologia · 2022Article
- Retrospective analysis of endocarditis patients to investigate the eligibility for oral antibiotic treatment in routine daily practice.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2021Article
- Structural insights into the inhibition of bacterial RecA by naphthalene polysulfonated compounds.iScience · 2021Article
- Long-term antibiotic therapy in patients with surgery-indicated not undergoing surgery infective endocarditis.Cardiology journal · 2021Article
- Practice Patterns of Infectious Diseases Physicians in Transitioning From Intravenous to Oral Therapy in Patients With Bacteremia.Open forum infectious diseases · 2020Article
- Infective Endocarditis in Persons Who Use Drugs: Epidemiology, Current Management, and Emerging Treatments.Infectious disease clinics of North America · 2020Review
- Article
- Evaluation of a Paradigm Shift From Intravenous Antibiotics to Oral Step-Down Therapy for the Treatment of Infective Endocarditis: A Narrative Review.JAMA internal medicine · 2020Review
- Current Evidence on Oral Antibiotics for Infective Endocarditis: A Narrative Review.Cardiology and therapy · 2019Review
- The novel use of oral antibiotic monotherapy in prosthetic valve endocarditis caused by Finegoldia magna: a case study.Journal of cardiothoracic surgery · 2019Article
- Assessment of the feasibility of a partial oral regimen for antibiotic therapy of endocarditis.Internal and emergency medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of oral antibiotic therapy in treating infective endocarditis (IE) is not well established.
methodsWe searched MEDLINE, EMBASE and Scopus for studies in which oral antibiotic therapy was used for the treatment of IE.
resultsSeven observational studies evaluating the use oral beta-lactams (five), oral ciprofloxacin in combination with rifampin (one), and linezolid (one) for the treatment of IE caused by susceptible bacteria reported cure rates between 77% and 100%. Two other observational studies using aureomycin or sulfonamide, however, had failure rates >75%. One clinical trial comparing oral amoxicillin versus intravenous ceftriaxone for streptococcal IE reported 100% cure in both arms but its reporting had serious methodological limitations. One small clinical trial (n = 85) comparing oral ciprofloxacin and rifampin versus conventional intravenous antibiotic therapy for uncomplicated right-sided S. aureus IE in intravenous drug users (IVDUs) reported cure rates of 89% and 90% in each arm, respectively (P =0.9); however, drug toxicities were more common in the latter group (62% versus 3%; P <0.01). Major limitations of this trial were lack of allocation concealment and blinding at the delivery of the study drug(s) and assessment of outcomes.
conclusionReported cure rates for IE treated with oral antibiotic regimens vary widely. The use of oral ciprofloxacin in combination with rifampin for uncomplicated right-sided S. aureus IE in IVDUs is supported by one small clinical trial of relatively good quality and could be considered when conventional IV antibiotic therapy is not possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.