Evidence map›Paper›PMID 24624370›Full record

ReviewFrontiers in pediatrics2014

From genes to health - challenges and opportunities.

Muhammad Ramzan Manwar Hussain, Asifullah Khan, Hussein Sheikh Ali Mohamoud

Abstract readReview
In one paragraph

Review in Frontiers in pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Muhammad Ramzan Manwar HussainPrincess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases (PACER-HD), Department of Genetic Medicine, King Abdulaziz University , Jeddah , Saudi Arabia.
Asifullah KhanDepartment of Biochemistry, Abdul Wali Khan University , Mardan , Pakistan.
Hussein Sheikh Ali MohamoudPrincess Al-Jawhara Al-Brahim Center of Excellence in Research of Hereditary Diseases (PACER-HD), Department of Genetic Medicine, King Abdulaziz University , Jeddah , Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In genome science, the advancement in high-throughput sequencing technologies and bioinformatics analysis is facilitating the better understanding of Mendelian and complex trait inheritance. Charting the genetic basis of complex diseases - including pediatric cancer, and interpreting huge amount of next-generation sequencing data are among the major technical challenges to be overcome in order to understand the molecular basis of various diseases and genetic disorders. In this review, we provide insights into some major challenges currently hindering a better understanding of Mendelian and complex trait inheritance, and thus impeding medical benefits to patients.

Indexed as

challengesgenomicsMendelian puzzlesnext-generation sequencingpediatric cancer

Identifiers

PMID24624370
PMCPMC3939617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.