Evidence map›Paper›PMID 24624343›Full record

ArticleAnnals of laboratory medicine2014

Novel markers of early neutrophilic and monocytic engraftment after hematopoietic stem cell transplantation.

Jimin Kahng, Seung-Ah Yahng, Jae Wook Lee, Yonggoo Kim, Myungshin Kim, Eun-Jee Oh, Yeon-Joon Park, Jong Wook Lee, Bin Cho, Kyungja Han

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Article in Annals of laboratory medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jimin KahngDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Seung-Ah YahngDepartment of Hematology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jae Wook LeeDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yonggoo KimDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Myungshin KimDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Eun-Jee OhDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yeon-Joon ParkDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jong Wook LeeDepartment of Hematology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Bin ChoDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kyungja HanDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNumerous studies tried to find new markers that after hematopoietic stem cell transplantation predict engraftment earlier than the conventional marker, absolute neutrophil count (ANC >500/µL). Early engraftment prediction can be achieved by a marker that reflects the release of neutrophils and monocytes into the leukopenic peripheral blood.

methodsWe analyzed blood cell parameters, including cell population data such as volume, conductivity, and light scatter in 77 patients who underwent HSCT (allogeneic, n=63; autologous, n=11) to detect possible markers.

resultsWe identified 2 early engraftment markers of neutrophils (NEUTRO) and monocytes (MONO); a pair of mean-volume-neutrophils (MNV) and mean-conductivity-neutrophils (MNC) for NEUTRO; and a pair of mean-volume-monocytes (MMV) and mean-conductivity-monocytes (MMC) for MONO. The new markers showed distinct patterns for early engraftment wherein 1) on the engraftment day, MNV peaked as MNC notched simultaneously for every case, and 2) MMV peaked as MMC notched simultaneously in most cases. Engraftment was predicted 3.8±2.7 days earlier than by ANC in 74 successful engraftment cases by using NEUTRO and/or MONO: 1) 72 cases (97.3%), in which NEUTRO and/or MONO predicted earlier engraftment than ANC, 2) 1 case, in which the 3 markers predicted engraftment on the same day, and 3) 1 case, in which NEUTRO predicted engraftment on the same day as ANC and MONO failed to predict engraftment.

conclusionsBy analyzing the data from daily complete blood counts, engraftment can be predicted approximately 4 days earlier than ANC >500/µL using NEUTRO as a base marker and MONO as a supplementary marker.

Indexed as

Hematopoietic Stem Cell TransplantationAdolescentAdultChildChild, PreschoolFemaleHematopoietic Stem CellsHumansInfantLeukocyte CountMaleMiddle AgedMonocytesNeutrophilsTime FactorsTransplantation, AutologousEngraftmentHSCTMarkerMonocytesNeutrophils

Identifiers

PMID24624343
PMCPMC3948839

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