Evidence map›Paper›PMID 24624331›Full record

ReviewRedox biology2014

Role of advanced glycation end products in cellular signaling.

Christiane Ott, Kathleen Jacobs, Elisa Haucke, Anne Navarrete Santos, Tilman Grune, Andreas Simm

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Redox biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 553 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
553citing papers in PubMed, 4 pooled it
45.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

553 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1,106 citations in OpenAlex.

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493 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christiane OttDepartment of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, 07743 Jena, Germany.
Kathleen JacobsClinic for Cardiothoracic Surgery, University Hospital Halle (Saale), Martin-Luther-University of Halle-Wittenberg, Ernst-Grube Strasse 40, D-06120 Halle (Saale), Germany.
Elisa HauckeInstitute for Anatomy and Cell Biology, Faculty of Medicine, Martin-Luther-University of Halle-Wittenberg, 06108 Halle (Saale), Germany.
Anne Navarrete SantosInstitute for Anatomy and Cell Biology, Faculty of Medicine, Martin-Luther-University of Halle-Wittenberg, 06108 Halle (Saale), Germany.
Tilman GruneDepartment of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, 07743 Jena, Germany.
Andreas SimmClinic for Cardiothoracic Surgery, University Hospital Halle (Saale), Martin-Luther-University of Halle-Wittenberg, Ernst-Grube Strasse 40, D-06120 Halle (Saale), Germany.
Martin Luther University Halle-Wittenberg · DEFriedrich Schiller University Jena · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Improvements in health care and lifestyle have led to an elevated lifespan and increased focus on age-associated diseases, such as neurodegeneration, cardiovascular disease, frailty and arteriosclerosis. In all these chronic diseases protein, lipid or nucleic acid modifications are involved, including cross-linked and non-degradable aggregates, such as advanced glycation end products (AGEs). Formation of endogenous or uptake of dietary AGEs can lead to further protein modifications and activation of several inflammatory signaling pathways. This review will give an overview of the most prominent AGE-mediated signaling cascades, AGE receptor interactions, prevention of AGE formation and the impact of AGEs during pathophysiological processes.

Indexed as

AgingAnimalsBone and BonesDietary ProteinsGlycation End Products, AdvancedHumansHyperglycemiaImmune SystemInflammationLipid PeroxidationLungMaillard ReactionModels, BiologicalNeuronsNF-kappa BOxidative StressDietary ProteinsGlycation End Products, AdvancedNF-kappa BPolymerspolyolProtein AggregatesReactive Nitrogen SpeciesReactive Oxygen SpeciesReceptor for Advanced Glycation End ProductsReceptors, ImmunologicReceptors, ScavengerADAMST, a disintegrin and metalloproteinase with a thrombospondin type 1 motifAdvanced glycation end productsAGE, advanced glycation end productsAge-associated diseasesAGE-receptorsAggregatesAgingE, from embryonic dayEGFR, epidermal growth factor receptorERK, extracellular-signal regulated kinaseF3NK, fructosamine 3-phosphokinaseFKHRL1, forkhead transcription factorHDL, high density lipoproteinHMGB1, high-mobility-group-protein B1HNE, 4-hydroxy-trans-2-nonenalJak1/2, Janus kinase 1/2LDL, low density lipoproteinMDA, malondialdehydeMEKK, mitogen-activated protein/ERK kinase kinasesMnSOD, manganese superoxide dismutaseNF-κBNf-κB, nuclear factor-light-chain-enhancer of activated BOxidative stressPIK3, phosphoinositol 3 kinaseRAGERAGE, receptor of AGEsRCC, reactive carbonyl compoundsReactive carbonyl compoundsS100B, S100 calcium binding protein BSignalingSIRt1, NAD+-dependent deacetylase and survival factor 1SR-A, scavenger receptor class AStat 1/2, signal transducers and activators of transcription 1/2VSMC, vascular smooth muscle cells

Identifiers

PMID24624331
PMCPMC3949097
OpenAlexW2086327676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.