ArticleJundishapur journal of natural pharmaceutical products2013
Pyridine Based Chalcones: Synthesis and Evaluation of Antioxidant Activity of 1-Phenyl-3-(pyridin-2-yl)prop-2-en-1-one Derivatives.
Article in Jundishapur journal of natural pharmaceutical products, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Design, synthesis, biological evaluation, and in silico characterization of chalcone derivatives as antidiabetic hits.Scientific reports · 2026Article
- Synthesis, antimicrobial evaluation, ADMET prediction, molecular docking and dynamics studies of pyridine and thiophene moiety-containing chalcones.Royal Society open science · 2025Article
- Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Design, synthesis, characterization, and biological evaluation of nicotinoyl thioureas as antimicrobial and antioxidant agents.The Journal of antibiotics · 2021Article
- Pyridine azo disperse dye derivatives and their selenium nanoparticles (SeNPs): synthesis, fastness properties, and antimicrobial evaluations.International journal of nanomedicine · 2019Article
- Heterocyclization of polarized system: synthesis, antioxidant and anti-inflammatory 4-(pyridin-3-yl)-6-(thiophen-2-yl) pyrimidine-2-thiol derivatives.Chemistry Central journal · 2018Article
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Abstract
backgroundNatural chalcones and also their synthetic derivatives have attracted increasing attention due to various pharmacological applications. Development and discovery of new chalcones with antioxidant activities is one of the attracting areas in medicinal and natural product chemistry.
objectivesIn the present study, a new series of pyridine based chalcones was synthesized and their antioxidant capacity was evaluated by beta carotene bleaching (BCB), DPPH free radical scavenging, ferrous ion chelating (FIC) activity and Trolox equivalent antioxidant capacity (TEAC) methods. MATERIALS AND
methodsAll compounds were synthesized via an aldol condensation procedure in methanol or ethanol solvent at room temperature and characterization was carried out by (1)HNMR, IR and MS spectroscopic methods. Related melting points were also measured for each compound.
resultsFortunately, compounds 3e (16.53 ± 1.21 µg/mL), 3g (58.85 ± 1.10 µg/mL) and 3i (58.73 ± 12.94 µg/mL) showed higher antioxidant activity (EC50 ± SD) in comparison with quercetin (87.24 ± 3.93 µg/mL) as reference agent in ferrous ion chelating method. Furthermore, compounds 3g (4.82 ± 0.11 µg/mL) and 3h (6.33 ± 0.30 µg/mL) also exhibited an acceptable antioxidant property compared to Trolox (3.83 ± 0.22 µg/mL) in TEAC method. None of synthesized compounds demonstrated significant antioxidant activity in DPPH free radical scavenging as well as beta carotene bleaching tests.
conclusionsAccording to the obtained data, synthesized pyridine based chalcones (3a-3j) could be proposed as potential antioxidant lead compounds.
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