Evidence map›Paper›PMID 24624157›Full record

ArticleJundishapur journal of natural pharmaceutical products2012

Relationship between cell compatibility and elastic modulus of silicone rubber/organoclay nanobiocomposites.

Motahare Sadat Hosseini, Mohammad Tazzoli-Shadpour, Issa Amjadi, Nooshin Haghighipour, Mohammad Ali Shokrgozar, Mehri Ghafourian Boroujerdnia

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Jundishapur journal of natural pharmaceutical products, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Motahare Sadat HosseiniBiomedical Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, Tehran, IR Iran ; Polymer Group, Faculty of Polymer Engineering and Color Technology (Center of Excellence), Amirkabir University of Technology, Tehran, IR Iran.
Mohammad Tazzoli-ShadpourBiomedical Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, Tehran, IR Iran.
Issa AmjadiBiomedical Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, Tehran, IR Iran.
Nooshin HaghighipourNational Cell Bank of Iran, Pasteur Institute of Iran, Tehran, IR Iran.
Mohammad Ali ShokrgozarNational Cell Bank of Iran, Pasteur Institute of Iran, Tehran, IR Iran.
Mehri Ghafourian BoroujerdniaNanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran ; Immunology Department, Medical College, Ahvaz Jundishapur University of Medical Science, Ahvaz, IR Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubstrates in medical science are hydrophilic polymers undergoing volume expansion when exposed to culture medium that influenced on cell attachment. Although crosslinking by chemical agents could reduce water uptake and promote mechanical properties, these networks would release crosslinking agents. In order to overcome this weakness, silicone rubber is used and reinforced by nanoclay.

objectivesAttempts have been made to prepare nanocomposites based on medical grade HTV silicone rubber (SR) and organo-modified montmorillonite (OMMT) nanoclay with varying amounts of clay compositions. MATERIALS AND

methodsIncorporation of nanocilica platelets into SR matrix was carried out via melt mixing process taking advantage of a Brabender internal mixer. The tensile elastic modulus of nanocomposites was measured by performing tensile tests on the samples. Produced polydimetylsiloxane (PDMS) composites with different flexibilities and crosslink densities were employed as substrates to investigate biocompatibility, cell compaction, and differential behaviors.

resultsThe results presented here revealed successful nanocomposite formation with SR and OMMT, resulting in strong PDMS-based materials. The results showed that viability, proliferation, and spreading of cells are governed by elastic modulus and stiffness of samples. Furthermore, adipose derived stem cells (ADSCs) cultured on PDMS and corresponding nanocomposites could retain differentiation potential of osteocytes in response to soluble factors, indicating that inclusion of OMMT would not prevent osteogenic differentiation. Moreover, better spread out and proliferation of cells was observed in nanocomposite samples.

conclusionsConsidering cell behavior and mechanical properties of nanobiocomposites it could be concluded that silicone rubber substrate filled by nanoclay are a good choice for further experiments in tissue engineering and medical regeneration due to its cell compatibility and differentiation capacity.

Indexed as

Cytotoxicity TestsElastic ModulusNanocomposite

Identifiers

PMID24624157
PMCPMC3941853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.