ArticleFrontiers in genetics2014
Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs.
Article in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Article
- Integrated Multi-Omics for Novel Aging Biomarkers and Antiaging Targets.Biomolecules · 2021Review
- Review
- Exposure to Dimethyl Selenide (DMSe)-Derived Secondary Organic Aerosol Alters Transcriptomic Profiles in Human Airway Epithelial Cells.Environmental science & technology · 2019Article
- Review
- Differences in intra-tumoral macrophage infiltration and radiotherapy response among intrinsic subtypes in pT1-T2 breast cancers treated with breast-conserving surgery.Virchows Archiv : an international journal of pathology · 2019Article
- Understanding the Early Biological Effects of Isoprene-Derived Particulate Matter Enhanced by Anthropogenic Pollutants.Research report (Health Effects Institute) · 2019Article
- Using the drug-protein interactome to identify anti-ageing compounds for humans.PLoS computational biology · 2019Article
- Gene expression-based drug repurposing to target aging.Aging cell · 2018Article
- Article
- Data aggregation at the level of molecular pathways improves stability of experimental transcriptomic and proteomic data.Cell cycle (Georgetown, Tex.) · 2017Article
- Gene Expression Profiling in Human Lung Cells Exposed to Isoprene-Derived Secondary Organic Aerosol.Environmental science & technology · 2017Article
- Geroprotectors: A Unified Concept and Screening Approaches.Aging and disease · 2017Review
- Effects of Abies sibirica terpenes on cancer- and aging-associated pathways in human cells.Oncotarget · 2016Article
- Article
- Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.Aging cell · 2016Review
- Large-scale profiling of signalling pathways reveals an asthma specific signature in bronchial smooth muscle cells.Oncotarget · 2016Article
- Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes.Nucleic acids research · 2016Article
- MiRImpact, a new bioinformatic method using complete microRNA expression profiles to assess their overall influence on the activity of intracellular molecular pathways.Cell cycle (Georgetown, Tex.) · 2016Article
- Article
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Authors and funding
5 authors.
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Abstract
The major challenges of aging research include absence of the comprehensive set of aging biomarkers, the time it takes to evaluate the effects of various interventions on longevity in humans and the difficulty extrapolating the results from model organisms to humans. To address these challenges we propose the in silico method for screening and ranking the possible geroprotectors followed by the high-throughput in vivo and in vitro validation. The proposed method evaluates the changes in the collection of activated or suppressed signaling pathways involved in aging and longevity, termed signaling pathway cloud, constructed using the gene expression data and epigenetic profiles of young and old patients' tissues. The possible interventions are selected and rated according to their ability to regulate age-related changes and minimize differences in the signaling pathway cloud. While many algorithmic solutions to simulating the induction of the old into young metabolic profiles in silico are possible, this flexible and scalable approach may potentially be used to predict the efficacy of the many drugs that may extend human longevity before conducting pre-clinical work and expensive clinical trials.
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