ReviewFrontiers in physiology2014
Cerebral oxygenation and hyperthermia.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Effects of Acute Heat and Cold Exposures at Rest or during Exercise on Subsequent Energy Intake: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Cognitive Neuroelectrical Activity During Preparation for Exercise Under Hyperthermia.Exercise and sport sciences reviews · 2026Review
- Determinants of Brain Tissue Normoxia in Patients with Large Spontaneous Intracerebral Hemorrhage.Neurocritical care · 2026Article
- Cerebrovascular regulation during heat stress.Experimental physiology · 2026Review
- Brain strain: Blood flow and metabolism in environmental extremes.Experimental physiology · 2026Review
- Modulation of cerebral blood flow and cognition by hyperthermia and hypoxia: An electroencephalographic event-related potentials perspective.Experimental physiology · 2025Review
- Traumatic brain injury graphing: A case study of Charles Whitman.Journal of forensic sciences · 2025Article
- Directional sensitivity analysis of the cerebral pressure-flow relationship during normothermia and moderate hyperthermia.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Burning fuels burns the brain's bioenergetic bridges: On the importance of physiological resilience.Experimental physiology · 2023Article
- Cerebral Oxygen Delivery and Consumption in Brain-Injured Patients.Journal of personalized medicine · 2022Review
- Temperature management during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.Frontiers in oncology · 2022Review
- Effect of Cyclic Heat Stress on Hypothalamic Oxygen Homeostasis and Inflammatory State in the Jungle Fowl and Three Broiler-Based Research Lines.Frontiers in veterinary science · 2022Article
- Case report: The physiology of a preventable tragedy -Near death in a hot tub.Clinical case reports · 2021Article
- Effects of passive heat stress and recovery on human cognitive function: An ERP study.PloS one · 2021Article
- An assessment of hypercapnia-induced elevations in regional cerebral perfusion during combined orthostatic and heat stresses.The journal of physiological sciences : JPS · 2020Article
- Mechanism and Treatment Related to Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy.Frontiers in molecular neuroscience · 2019Review
- Cerebral Oximetry for Detecting High-mortality Risk Patients with Cryptococcal Meningitis.Open forum infectious diseases · 2018Article
- Quantitative pharmacokinetic-pharmacodynamic modelling of baclofen-mediated cardiovascular effects using BP and heart rate in rats.British journal of pharmacology · 2016Article
- Mechanisms of orthostatic intolerance during heat stress.Autonomic neuroscience : basic & clinical · 2016Review
- Cerebral oxygenation in health and disease.Frontiers in physiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperthermia is associated with marked reductions in cerebral blood flow (CBF). Increased distribution of cardiac output to the periphery, increases in alveolar ventilation and resultant hypocapnia each contribute to the fall in CBF during passive hyperthermia; however, their relative contribution remains a point of contention, and probably depends on the experimental condition (e.g., posture and degree of hyperthermia). The hyperthermia-induced hyperventilatory response reduces arterial CO2 pressure (PaCO2) causing cerebral vasoconstriction and subsequent reductions in flow. During supine passive hyperthermia, the majority of recent data indicate that reductions in PaCO2 may be the primary, if not sole, culprit for reduced CBF. On the other hand, during more dynamic conditions (e.g., hemorrhage or orthostatic challenges), an inability to appropriately decrease peripheral vascular conductance presents a condition whereby adequate cerebral perfusion pressure may be compromised secondary to reductions in systemic blood pressure. Although studies have reported maintenance of pre-frontal cortex oxygenation (assessed by near-infrared spectroscopy) during exercise and severe heat stress, the influence of cutaneous blood flow is known to contaminate this measure. This review discusses the governing mechanisms associated with changes in CBF and oxygenation during moderate to severe (i.e., 1.0°C to 2.0°C increase in body core temperature) levels of hyperthermia. Future research directions are provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.