ArticleFrontiers in physiology2014
Neural-humoral responses during head-up tilt in healthy young white and black women.
Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Gender Difference in Orthostatic Vascular Stiffness Increase in Young Subjects.Diagnostics (Basel, Switzerland) · 2025Article
- The Importance of Orthostatic Increase in Pulse Wave Velocity in the Diagnosis of Early Vascular Aging.Journal of clinical medicine · 2024Article
- Sympathetic transduction at rest and during cold pressor test in young healthy non-Hispanic Black and White women.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Preclinical Orthostatic Abnormalities May Predict Early Increase in Vascular Stiffness in Different Age Groups: A Pilot Study.Diagnostics (Basel, Switzerland) · 2023Article
- Exaggerated blood pressure response to standing in young-to-middle-age subjects: prevalence and factors involved.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Article
- Young, non-Hispanic Black men and women exhibit divergent peripheral and cerebral vascular reactivity.Experimental physiology · 2022Article
- Impaired sympathetic neural recruitment during exercise pressor reflex activation in women with post-traumatic stress disorder.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Differential influences of dietary sodium on blood pressure regulation based on race and sex.Autonomic neuroscience : basic & clinical · 2021Review
- Effects of an Innovative Head-Up Tilt Protocol on Blood Pressure and Arterial Stiffness Changes.Journal of clinical medicine · 2021Article
- Sympathetic transduction in humans: recent advances and methodological considerations.American journal of physiology. Heart and circulatory physiology · 2021Review
- Neural control of blood pressure during pregnancy in humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Review
- Racial disparities in cardiovascular disease risk: mechanisms of vascular dysfunction.American journal of physiology. Heart and circulatory physiology · 2019Review
- Sympathetic neural reactivity to mental stress differs in black and non-Hispanic white adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Sympathetic neural and cardiovascular responses during static handgrip exercise in women with a history of hypertensive pregnancy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Article
- Quantifying sympathetic neuro-haemodynamic transduction at rest in humans: insights into sex, ageing and blood pressure control.The Journal of physiology · 2016Article
- Neuro-humoral control during orthostasis in health and disease.Frontiers in physiology · 2014Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Young black women have higher prevalence of hypertension during pregnancy compared to white women, which may be attributable to differences in blood pressure (BP) regulation. We hypothesized that young normotensive black women would demonstrate augmented muscle sympathetic nerve activity (MSNA) and renal-adrenal responses to orthostasis. Fifteen white and ten black women (30 ± 4 vs. 32 ± 6 years; means ± SD) had haemodynamics and MSNA measured during baseline (BL), 30 and 60° head-up tilt (HUT), and recovery. Blood was drawn for catecholamines, direct renin, vasopressin, and aldosterone. BL brachial systolic BP (SBP: 107 ± 6 vs. 101 ± 9 mmHg) and diastolic BP (DBP: 62 ± 4 vs. 56 ± 7 mmHg) were higher in white women (both p < 0.05). Δ DBP (60° HUT-BL) was greater in black women compared to white (p < 0.05). Cardiac output and total peripheral resistance were similar between groups. MSNA burst frequency was higher in whites (BL: 16 ± 10 vs. 14 ± 9 bursts/min, main effect p < 0.05) and increased in both groups during HUT (60°: 39 ± 8 vs. 34 ± 13 bursts/min, p < 0.05 from BL). Noradrenaline was higher in white women during 60° HUT (60° HUT: 364 ± 102 vs. 267 ± 89 pg/ml, p < 0.05). Direct renin was higher and vasopressin and Δ aldosterone tended to be higher in blacks (BL, direct renin: 12.1 ± 5.0 vs. 14.4 ± 3.7 pg/ml, p < 0.05; BL, vasopressin: 0.4 ± 0.0 vs. 1.6 ± 3.6 pg/ml, p = 0.065; Δ aldosterone: -0.9 ± 5.1 vs. 3.8 ± 7.5 ng/ml; p = 0.069). These results suggest that young normotensive white women may rely on sympathetic neural activity more so than black women who have a tendency to rely on the renal-adrenal system to regulate BP during an orthostatic stress.
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