ArticleFrontiers in human neuroscience2014
Artemis 123: development of a whole-head infant and young child MEG system.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Magnetoencephalography and the infant brain.NeuroImage · 2019Pooled it
- Advanced neuroimaging and its role in predicting neurodevelopmental outcomes in very preterm infants.Seminars in perinatology · 2016Pooled it
- Resting-state periodic and aperiodic brain oscillations from birth to preschool years: Aperiodic maturity predicts developmental course.Developmental cognitive neuroscience · 2026Article
- Revolutionizing Pediatric Neurophysiology With Magnetoencephalography.Psychophysiology · 2026Review
- Expanding the toolkit: OPMs for studying the developing brain.Imaging neuroscience (Cambridge, Mass.) · 2026Review
- The maturation of infant and toddler visual cortex neural activity and associations with fine motor performance.Developmental cognitive neuroscience · 2025Article
- Beyond sensitivity: what are the enabling opportunities of OPM-MEG?Frontiers in medical technology · 2025Article
- Paediatric magnetoencephalography and its role in neurodevelopmental disorders.The British journal of radiology · 2024Review
- Functional and structural maturation of auditory cortex from 2 months to 2 years old.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Article
- A comparison of resting-state eyes-closed and dark-room alpha-band activity in children.Psychophysiology · 2023Article
- Maturational trajectory of fusiform gyrus neural activity when viewing faces: From 4 months to 4 years old.Frontiers in human neuroscience · 2022Article
- Improving Localization Accuracy of Neural Sources by Pre-processing: Demonstration With Infant MEG Data.Frontiers in neurology · 2022Article
- Article
- Magnetic Source Imaging and Infant MEG: Current Trends and Technical Advances.Brain sciences · 2019Review
- Exploring early human brain development with structural and physiological neuroimaging.NeuroImage · 2019Review
- Magnetoencephalography: Clinical and Research Practices.Brain sciences · 2018Review
- IFCN-endorsed practical guidelines for clinical magnetoencephalography (MEG).Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Review
- Neonatal brain resting-state functional connectivity imaging modalities.Photoacoustics · 2018Review
Corrections and comments
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Authors and funding
23 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundA major motivation in designing the new infant and child magnetoencephalography (MEG) system described in this manuscript is the premise that electrophysiological signatures (resting activity and evoked responses) may serve as biomarkers of neurodevelopmental disorders, with neuronal abnormalities in conditions such as autism spectrum disorder (ASD) potentially detectable early in development. Whole-head MEG systems are generally optimized/sized for adults. Since magnetic field produced by neuronal currents decreases as a function of distance(2) and infants and young children have smaller head sizes (and thus increased brain-to-sensor distance), whole-head adult MEG systems do not provide optimal signal-to-noise in younger individuals. This spurred development of a whole-head infant and young child MEG system - Artemis 123.
methodsIn addition to describing the design of the Artemis 123, the focus of this manuscript is the use of Artemis 123 to obtain auditory evoked neuromagnetic recordings and resting-state data in young children. Data were collected from a 14-month-old female, an 18-month-old female, and a 48-month-old male. Phantom data are also provided to show localization accuracy.
resultsExamination of Artemis 123 auditory data showed generalizability and reproducibility, with auditory responses observed in all participants. The auditory MEG measures were also found to be manipulable, exhibiting sensitivity to tone frequency. Furthermore, there appeared to be a predictable sensitivity of evoked components to development, with latencies decreasing with age. Examination of resting-state data showed characteristic oscillatory activity. Finally, phantom data showed that dipole sources could be localized with an error less than 0.5 cm.
conclusionsArtemis 123 allows efficient recording of high-quality whole-head MEG in infants four years and younger. Future work will involve examining the feasibility of obtaining somatosensory and visual recordings in similar-age children as well as obtaining recordings from younger infants. Thus, the Artemis 123 offers the promise of detecting earlier diagnostic signatures in such neurodevelopmental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.