ArticleInternational journal of nanomedicine2014
Effects of titania nanotubes with or without bovine serum albumin loaded on human gingival fibroblasts.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Nano-Based Approaches in Surface Modifications of Dental Implants: A Literature Review.Molecules (Basel, Switzerland) · 2024Review
- Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant.International journal of nanomedicine · 2024Review
- Craniofacial therapy: advanced local therapies from nano-engineered titanium implants to treat craniofacial conditions.International journal of oral science · 2023Review
- Dental Implant Nano-Engineering: Advances, Limitations and Future Directions.Nanomaterials (Basel, Switzerland) · 2021Review
- The Early Adhesion Effects of Human Gingival Fibroblasts on Bovine Serum Albumin Loaded Hydrogenated Titanium Nanotube Surface.Molecules (Basel, Switzerland) · 2021Article
- Local and Systemic In Vivo Responses to Osseointegrative Titanium Nanotube Surfaces.Nanomaterials (Basel, Switzerland) · 2021Article
- Novel Yttria-Stabilized Zirconium Oxide and Lithium Disilicate Coatings on Titanium Alloy Substrate for Implant Abutments and Biomedical Application.Materials (Basel, Switzerland) · 2020Article
- Biofunctionalization of Microgroove Surfaces with Antibacterial Nanocoatings.BioMed research international · 2020Article
- Enhanced Human Gingival Fibroblast Response and ReducedBioMed research international · 2020Article
- Oriented Cell Alignment Induced by a Nanostructured Titanium Surface Enhances Expression of Cell Differentiation Markers.Nanomaterials (Basel, Switzerland) · 2019Article
- Serum albumin-coated bone allograft (BoneAlbumin) results in faster bone formation and mechanically stronger bone in aging rats.Journal of tissue engineering and regenerative medicine · 2019Article
- Surface functionalization of TiOBiomedical engineering online · 2018Article
- Bone-Albumin filling decreases donor site morbidity and enhances bone formation after anterior cruciate ligament reconstruction with bone-patellar tendon-bone autografts.International orthopaedics · 2016Article
- Study of a new bone-targeting titanium implant-bone interface.International journal of nanomedicineArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modifying the surface of the transmucosal area is a key research area because this process positively affects the three functions of implants: attachment to soft tissue, inhibiting bacterial biofilm adhesion, and the preservation of the crestal bone. To exploit the potential of titania nanotube arrays (TNTs) with or without using bovine serum albumin (BSA) to modify the surface of a dental implant in contact with the transmucosal area, BSA was loaded into TNTs that were fabricated by anodizing Ti sheets; the physical characteristics of these arrays, including their morphology, chemical composition, surface roughness, contact angle, and surface free energy (SFE), were assessed. The effect of Ti surfaces with TNTs or TNTs-BSA on human gingival fibroblasts (HGFs) was determined by analyzing cell morphology, early adhesion, proliferation, type I collagen (COL-1) gene expression, and the extracellular secretion of COL-1. The results indicate that early HGF adhesion and spreading behavior is positively correlated with surface characteristics, including hydrophilicity, SFE, and surface roughness. Additionally, TNT surfaces not only promoted early HGF adhesion, but also promoted COL-1 secretion. BSA-loaded TNT surfaces promoted early HGF adhesion, while suppressing late proliferation and COL-1 secretion. Therefore, TNT-modified smooth surfaces are expected to be applicable for uses involving the transmucosal area. Further study is required to determine whether BSA-loaded TNT surfaces actually affect closed loop formation of connective tissue because BSA coating actions in vivo are very rapid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.