ArticleInternational journal of nanomedicine2014
Facile method for the synthesis of silver nanoparticles using 3-hydrazino-isatin derivatives in aqueous methanol and their antibacterial activity.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Discovery and prospects of new heterocyclic Isatin-hydrazide derivative with a novel role as estrogen receptor α degrader in breast cancer cells.Frontiers in chemistry · 2024Article
- Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis,RSC advances · 2023Article
- Evaluation of silver nanoparticles in cosmeceutical and potential biosafety complications.Saudi journal of biological sciences · 2022Review
- Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates.Molecules (Basel, Switzerland) · 2020Article
- Synthesis and Characterization of Macrocyclic Chiral Tröger's Base Phenhomazine Candidates as Anticancer Agent.Frontiers in chemistry · 2020Article
- Effect of Structure on Charge Distribution in the Isatin Anions in Aprotic Environment: Spectral Study.Molecules (Basel, Switzerland) · 2017Article
- Synthesis, Characterization, and Anti-Cancer Activity of Some New N'-(2-Oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazones Derivatives.Molecules (Basel, Switzerland) · 2015Article
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4 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
introductionA new method for preparation of silver nanoparticles (AgNPs) based on using hydrazino-isatin derivatives in an aqueous methanol reaction medium is reported here. AgNPs were prepared using silver nitrate solubilized in a water core as the source of silver ions and 3-hydrazino-isatin derivatives (3-hydrazino-isatin [IsH] and 1-benzyl-3-hydrazino-isatin [BIsH]) solubilized in methanol core as a reducing agent. The proposed method is effective, rapid, and convenient. X-ray diffraction (XRD), energy dispersive X-ray analysis, scanning electron microscope (SEM) and transmission electron microscopy (TEM) were used for characterization of the AgNPs. The TEM micrographs confirmed that the nanopowders consist of well-dispersed agglomerates of grains with a narrow size distribution of 18-21 nm and 17-20 nm. The AgNPs, as well as BIsH, showed high antimicrobial and bactericidal activity against the Gram-positive Bacillus subtilis and Gram-negative Micrococcus luteus and Proteus vulgaris, as well as antifungal activities against Saccharomyces cerevisiae. On the other hand, they were not effective against the Gram-negative Escherichia coli. PURPOSE: A simple, effective, rapid, and convenient chemical reduction method for the synthesis of AgNPs in an aqueous methanol reaction medium using hydrazino-isatin derivatives and studying their antibacterial effect.
resultsIsH and BIsH are remarkably powerful reductants for Ag+ ions in an aqueous methanol medium, which could be considered as a simple chemical reduction method for formation of AgNPs. The AgNP formation depends on the solubility of the hydrazino-isatin derivatives. BIsH gave more AgNPs than IsH, as observed from XRD. The formation of AgNPs is attributed to the adsorption of hydrazine derivatives and/or interparticle interaction on the surface of AgNP through electrostatic interactions between the lone pair electrons of the hydrazino group (C=N-NH2) and the positive surface of AgNPs. AgNPs and BIsH showed high antimicrobial and bacterial activity.
conclusionIn summary, it is shown that IsH and BIsH are remarkably powerful reductants for Ag+ ions in an aqueous methanol medium. BIsH gave more AgNPs than IsH, as observed from XRD due to better solubility of the BIsH than IsH in aqueous-methanol. The formation of AgNPs is attributed to the adsorption of hydrazine derivatives and/or interparticle interaction on the surface of AgNPs through electrostatic interactions between the lone pair electrons of the hydrazino group (C=N-NH2) and the positive surface of AgNPs. The AgNps as well as BIsH ligand showed high antimicrobial and bactericidal activity.
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