Evidence map›Paper›PMID 24623877›Full record

ArticleThe Korean journal of parasitology2014

Expression of translationally controlled tumor protein (TCTP) gene of Dirofilaria immitis guided by transcriptomic screening.

Yan Fu, Jingchao Lan, Xuhang Wu, Deying Yang, Zhihe Zhang, Huaming Nie, Rong Hou, Runhui Zhang, Wanpeng Zheng, Yue Xie and 9 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of parasitology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Brown Spider (Toxins · 2019
    Review
  3. Molecular Detection ofIranian journal of parasitology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Yan FuDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Jingchao LanThe Sichuan Key Laboratory for Conservation Biology on Endangered Wildlife, Developing Toward a State Key Laboratory for China, Chengdu Research Base of Giant Panda Breeding, Chengdu, Sichuan 610081, China.
Xuhang WuDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Deying YangDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Zhihe ZhangThe Sichuan Key Laboratory for Conservation Biology on Endangered Wildlife, Developing Toward a State Key Laboratory for China, Chengdu Research Base of Giant Panda Breeding, Chengdu, Sichuan 610081, China.
Huaming NieDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Rong HouThe Sichuan Key Laboratory for Conservation Biology on Endangered Wildlife, Developing Toward a State Key Laboratory for China, Chengdu Research Base of Giant Panda Breeding, Chengdu, Sichuan 610081, China.
Runhui ZhangDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Wanpeng ZhengDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Yue XieDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Ning YanDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Zhi YangThe Sichuan Key Laboratory for Conservation Biology on Endangered Wildlife, Developing Toward a State Key Laboratory for China, Chengdu Research Base of Giant Panda Breeding, Chengdu, Sichuan 610081, China.
Chengdong WangThe Sichuan Key Laboratory for Conservation Biology on Endangered Wildlife, Developing Toward a State Key Laboratory for China, Chengdu Research Base of Giant Panda Breeding, Chengdu, Sichuan 610081, China.
Li LuoThe Sichuan Key Laboratory for Conservation Biology on Endangered Wildlife, Developing Toward a State Key Laboratory for China, Chengdu Research Base of Giant Panda Breeding, Chengdu, Sichuan 610081, China.
Li LiuThe Sichuan Key Laboratory for Conservation Biology on Endangered Wildlife, Developing Toward a State Key Laboratory for China, Chengdu Research Base of Giant Panda Breeding, Chengdu, Sichuan 610081, China.
Xiaobin GuDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Shuxian WangDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Xuerong PengDepartment of Chemistry, College of Life and Basic Science, Sichuan Agricultural University, Ya'an 625014, China.
Guangyou YangDepartment of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China.
Sichuan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dirofilaria immitis (heartworm) infections affect domestic dogs, cats, and various wild mammals with increasing incidence in temperate and tropical areas. More sensitive antibody detection methodologies are required to diagnose asymptomatic dirofilariasis with low worm burdens. Applying current transcriptomic technologies would be useful to discover potential diagnostic markers for D. immitis infection. A filarial homologue of the mammalian translationally controlled tumor protein (TCTP) was initially identified by screening the assembled transcriptome of D. immitis (DiTCTP). A BLAST analysis suggested that the DiTCTP gene shared the highest similarity with TCTP from Loa loa at protein level (97%). A histidine-tagged recombinant DiTCTP protein (rDiTCTP) of 40 kDa expressed in Escherichia coli BL21 (DE3) showed immunoreactivity with serum from a dog experimentally infected with heartworms. Localization studies illustrated the ubiquitous presence of rDiTCTP protein in the lateral hypodermal chords, dorsal hypodermal chord, muscle, intestine, and uterus in female adult worms. Further studies on D. immitis-derived TCTP are warranted to assess whether this filarial protein could be used for a diagnostic purpose.

Indexed as

AnimalsAnimal StructuresAntibodies, HelminthAntigens, HelminthBiomarkers, TumorCloning, MolecularDirofilaria immitisDisease Models, AnimalDogsEscherichia coliGene ExpressionMolecular Sequence DataMolecular WeightRecombinant Fusion ProteinsSequence Analysis, DNATumor Protein, Translationally-Controlled 1Antibodies, HelminthAntigens, HelminthBiomarkers, TumorRecombinant Fusion ProteinsTumor Protein, Translationally-Controlled 1Dirofilaria immitisdirofilariasisheartwormtranscriptometranslationally controlled tumor protein

Identifiers

PMID24623877
PMCPMC3948989
OpenAlexW2165376244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.