ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Farnesol-detecting olfactory neurons in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 110 citations in OpenAlex.
- SNMP1 Contributes to Sensitive Pheromone and Plant Volatile Detection in the Locust Olfactory System.International journal of molecular sciences · 2026Article
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- Convergence-divergence circuits for multimodal integration of innate and learned opponent valences.Frontiers in systems neuroscience · 2026Article
- Multi-unit recordings in the stick insectFrontiers in physiology · 2026Article
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- Differential modulation of feedforward inhibition reflects topographic organization in the olfactory system.Nature communications · 2025Article
- Transcriptome Screening and Identification of Chemosensory Genes in the Goji Berry Psyllid,Biology · 2025Article
- Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins.bioRxiv : the preprint server for biology · 2025Article
- Olfactory responses of the variegated fruit fly, Phortica variegata, an emerging vector of the zoonotic eyeworm Thelazia callipaeda, to ecologically relevant volatiles.Parasites & vectors · 2025Article
- Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins.Research square · 2025Article
- Targeted deletion of olfactory receptors inJournal of neurogenetics · 2024Article
- Evolution of connectivity architecture in the Drosophila mushroom body.Nature communications · 2024Article
- Short-term particulate matter contamination severely compromises insect antennal olfactory perception.Nature communications · 2023Article
- A rapid and bidirectional reporter of neural activity reveals neural correlates of social behaviors in Drosophila.Nature neuroscience · 2023Article
- Heterologous investigation of metabotropic and ionotropic odorant receptors in ab3A neurons ofFrontiers in molecular biosciences · 2023Article
- The specific expression patterns of sensory neuron membrane proteins are retained throughout the development of the desert locustCurrent research in insect science · 2023Article
- Review
- Review
- Mushroom body input connections form independently of sensory activity in Drosophila melanogaster.Current biology : CB · 2022Article
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4 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We set out to deorphanize a subset of putative Drosophila odorant receptors expressed in trichoid sensilla using a transgenic in vivo misexpression approach. We identified farnesol as a potent and specific activator for the orphan odorant receptor Or83c. Farnesol is an intermediate in juvenile hormone biosynthesis, but is also produced by ripe citrus fruit peels. Here, we show that farnesol stimulates robust activation of Or83c-expressing olfactory neurons, even at high dilutions. The CD36 homolog Snmp1 is required for normal farnesol response kinetics. The neurons expressing Or83c are found in a subset of poorly characterized intermediate sensilla. We show that these neurons mediate attraction behavior to low concentrations of farnesol and that Or83c receptor mutants are defective for this behavior. Or83c neurons innervate the DC3 glomerulus in the antennal lobe and projection neurons relaying information from this glomerulus to higher brain centers target a region of the lateral horn previously implicated in pheromone perception. Our findings identify a sensitive, narrowly tuned receptor that mediates attraction behavior to farnesol and demonstrates an effective approach to deorphanizing odorant receptors expressed in neurons located in intermediate and trichoid sensilla that may not function in the classical "empty basiconic neuron" system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.