ArticleArthritis & rheumatology (Hoboken, N.J.)2014
Modifications of gait as predictors of natural osteoarthritis progression in STR/Ort mice.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Inhibition of cyclin-dependent kinase 8 modulates chondrocyte transition to hypertrophy and provides in vivo protection against spontaneous osteoarthritis.Bone research · 2026Article
- Three-Month Administration of PB125 Modifies Histopathology, Redox Homeostasis, and Mobility in the Hartley Guinea Pig Model of Primary Osteoarthritis.Antioxidants (Basel, Switzerland) · 2026Article
- COMPREHENSIVE ANALYSIS OF MURINE GAIT DURING SKELETAL MATURATION.bioRxiv : the preprint server for biology · 2026Article
- Hidden in plain sound: the scientific potential of house mouse squeaks.Biology letters · 2025Review
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- Osteomodulin downregulation is associated with osteoarthritis development.Bone research · 2023Article
- Elucidation of the Underlying Mechanism of Gujian Oral Liquid Acting on Osteoarthritis through Network Pharmacology, Molecular Docking, and Experiment.BioMed research international · 2022Article
- Article
- Factors affecting the reliability of behavioral assessments for rodent osteoarthritis models.Laboratory animals · 2020Review
- Understanding the Molecular Mechanisms Underlying the Pathogenesis of Arthritis Pain Using Animal Models.International journal of molecular sciences · 2020Review
- A novel device to measure static hindlimb weight-bearing forces in pronograde rodents.Journal of neuroscience methods · 2019Article
- Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice.Osteoarthritis and cartilage · 2018Article
- A murine model for developmental dysplasia of the hip: ablation of CX3CR1 affects acetabular morphology and gait.Journal of translational medicine · 2017Article
- Article
- The STR/ort mouse model of spontaneous osteoarthritis - an update.Osteoarthritis and cartilage · 2017Review
- Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model.Annals of the rheumatic diseases · 2017Article
- Gait analysis methods for rodent models of arthritic disorders: reviews and recommendations.Osteoarthritis and cartilage · 2016Review
- Intermittent applied mechanical loading induces subchondral bone thickening that may be intensified locally by contiguous articular cartilage lesions.Osteoarthritis and cartilage · 2015Article
- Gait analysis methods for rodent models of osteoarthritis.Current pain and headache reports · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveOsteoarthritis (OA) is a common chronic disease for which disease-modifying therapies are not currently available. Studies to seek new targets for slowing the progress of OA rely on mouse models, but these do not allow for longitudinal monitoring of disease development. This study was undertaken to determine whether gait can be used to measure disease severity in the STR/Ort mouse model of spontaneous OA and whether gait changes are related to OA joint pain.
methodsGait was monitored using a treadmill-based video system. Correlations between OA severity and gait at 3 treadmill speeds were assessed in STR/Ort mice. Gait and pain behaviors of STR/Ort mice and control CBA mice were analyzed longitudinally, with monthly assessments.
resultsThe best speed to identify paw area changes associated with OA severity in STR/Ort mice was found to be 17 cm · seconds(-1) . Paw area was modified with age in CBA and STR/Ort mice, but this began earlier in STR/Ort mice and correlated with the onset of OA at 20 weeks of age. In addition, task noncompliance appeared at 20 weeks. Surprisingly, STR/Ort mice did not show any signs of pain with OA development, even when treated with the opioid antagonist naloxone, but did exhibit normal pain behaviors in response to complete Freund's adjuvant-induced arthritis.
conclusionThe present results identify an animal model in which OA severity and OA pain can be studied in isolation from one another. The findings suggest that paw area and treadmill noncompliance may be useful tools to longitudinally monitor nonpainful OA development in STR/Ort mice. This will help in providing a noninvasive means of assessing new therapies to slow the progression of OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.