ArticlePathogens and disease2014
High-content phenotypic screenings to identify inhibitors of Candida albicans biofilm formation and filamentation.
Article in Pathogens and disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- The power of many: when genetics met yeasts and high-throughput.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Shapeshifting fungi: How morphological transitions can influence pathogenesis.PLoS pathogens · 2026Article
- Niclosamide-loaded nanoparticles disrupt Candida biofilms and protect mice from mucosal candidiasis.PLoS biology · 2022Article
- A Simple 96-Well Plate-Based Method for Development of Candida Biofilms Under Static Conditions.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A Specific Mixture of Propolis and Carnosic Acid Triggers a Strong Fungicidal Action againstAntibiotics (Basel, Switzerland) · 2021Article
- Polymeric micelles with anti-virulence activity against Candida albicans in a single- and dual-species biofilm.Drug delivery and translational research · 2021Article
- Mechanistic Understanding ofFrontiers in microbiology · 2021Review
- Intestinal Infection ofFrontiers in microbiology · 2021Review
- Novel Bi-Factorial Strategy againstMicroorganisms · 2020Article
- Quorum Sensing Activity and Hyphal Growth by External Stimuli in the Entomopathogenic FungusInsects · 2020Article
- Virulence and biofilms as promising targets in developing antipathogenic drugs against candidiasis.Future science OA · 2020Review
- Article
- In Vitro Culturing and Screening of Candida albicans Biofilms.Current protocols in microbiology · 2018Article
- Chemistry and Hypoglycemic Activity of GPR119 Agonist ZB-16.Frontiers in endocrinology · 2018Article
- Assessment and Optimizations of Candida albicansAntimicrobial agents and chemotherapy · 2017Article
- Review
- Screening the Pathogen Box for Identification of Candida albicans Biofilm Inhibitors.Antimicrobial agents and chemotherapy · 2017Article
- Activity of Scorpion Venom-Derived Antifungal Peptides against Planktonic Cells ofFrontiers in microbiology · 2016Article
- Effect of silver nanoparticles on Candida albicans biofilms: an ultrastructural study.Journal of nanobiotechnology · 2015Article
- Garcinia xanthochymus Benzophenones Promote Hyphal Apoptosis and Potentiate Activity of Fluconazole against Candida albicans Biofilms.Antimicrobial agents and chemotherapy · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Candida species represent the main cause of opportunistic fungal infections worldwide, and Candida albicans remains the most common etiological agent of candidiasis, now the third to fourth most common nosocomial infection. These infections are typically associated with high morbidity and mortality, mainly due to the limited efficacy of current antifungal drugs. In C. albicans, morphogenetic conversions between yeast and filamentous forms and biofilm formation represent two important biological processes that are intimately associated with the biology of this fungus and also play important roles during the pathogenesis of candidiasis. We have performed cell-based phenotypic screens using three different chemical libraries from the National Cancer Institute's Open Chemical Repository collection and identified several compounds with inhibitory activity against C. albicans biofilm formation and/or filamentation. These phenotype-based approaches represent a prosperous alternative to conventional genetics and genomics techniques to address experimentally challenging and complex biological phenomena, such as biofilm formation and filamentation, while at the same time opening new possibilities for the development of new antifungal agents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.