ReviewThe American journal of pathology1988
Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology.
Review in The American journal of pathology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
152 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Endothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.Pediatrics · 2022Pooled it
- Effect of Helicobacter pylori infection on the risk of acute coronary syndrome: A systematic review and meta-analysis.Medicine · 2019Pooled it
- Relationship between hepatitis C virus (HCV) and insulin resistance, endothelial perturbation, and platelet activation in HIV-HCV-coinfected patients under highly active antiretroviral treatment.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2006Trial
- Clinical applications of PET imaging for evaluating treatment-induced vascular toxicity in oncology.Current opinion in hematology · 2026Review
- The cross-talk between NRF2 and apoptosis in cancer.Medical molecular morphology · 2025Review
- Review
- Article
- Review
- Multi-omics delineation of cytokine-induced endothelial inflammatory states.Communications biology · 2023Article
- Endothelial Dysfunction, Erectile Deficit and Cardiovascular Disease: An Overview of the Pathogenetic Links.Biomedicines · 2022Review
- Endothelial Cell Metabolism in Vascular Functions.Cancers · 2022Review
- Association Between Endophthalmitis and the Incidence of Acute Coronary Syndrome in Patients With Ankylosing Spondylitis: A Nationwide, Population-Based Cohort Study.Frontiers in immunology · 2022Article
- Diversity of Lipid Function in Atherogenesis: A Focus on Endothelial Mechanobiology.International journal of molecular sciences · 2021Review
- Immunomodulatory Expression of Cathelicidins Peptides in Pulp Inflammation and Regeneration: An Update.Current issues in molecular biology · 2021Review
- Acute Cerebrovascular Disorders and Vasculopathies Associated with Significant Mortality in SARS-CoV-2 Patients Admitted to The Intensive Care Unit in The New York Epicenter.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021Article
- Metabolic Reprogramming of Vascular Endothelial Cells: Basic Research and Clinical Applications.Frontiers in cell and developmental biology · 2021Review
- Bias in Medicine: Lessons Learned and Mitigation Strategies.JACC. Basic to translational science · 2021Review
- Review
- Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it.Immunological reviews · 2020Review
- The Tumor Vascular Endothelium as Decision Maker in Cancer Therapy.Frontiers in oncology · 2018Review
92 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The concept of endothelial cell activation has been extremely useful in understanding endothelial cell function. The morphologic definition of activation from the 1960s has been replaced by a cell biologic definition in the 1980s, but recent studies have suggested that these phenomena are two aspects of the same processes. Moreover, the initial distinction of endothelial cell activation, a beneficial reaction, from injury and dysfunction, a harmful sequence, has become more complex as clinical studies have revealed that activation can produce dysfunction, with or without injury. Most importantly, as our in vivo studies indicate, the concept of activation is a testable hypothesis, as modern immunochemical and molecular biologic techniques have been employed to bridge the gap between in vitro culture experiments and patient-based clinical research.
Indexed as
Identifiers
2462353PMC1880803What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.