ArticlePharmaceutical research2014
Prediction of passive drug permeability across the blood-retinal barrier.
Article in Pharmaceutical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- MegaEye: Applying multiple machine learning approaches to identify oral compounds with ocular bioactivity.Artificial intelligence in the life sciences · 2025Article
- Theoretical and Experimental Studies of the Dynamic Damage of Endothelial Cellular Networks Under Ultrasound Cavitation.Cellular and molecular bioengineering · 2025Article
- Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy.Frontiers in endocrinology · 2022Review
- Influences of advanced glycosylation end products on the inner blood-retinal barrier in a co-culture cell modelOpen life sciences · 2020Article
- Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach.Nanomaterials (Basel, Switzerland) · 2019Review
- Structural dynamics of tight junctions modulate the properties of the epithelial barrier.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to develop a computational model of the physical barrier function of the outer blood-retinal barrier (BRB), which is vital for normal retinal function. To our best knowledge no comprehensive models of BRB has been reported.
methodsThe model construction is based on the three-layered structure of the BRB: retinal pigment epithelium (RPE), Bruch's membrane and choriocapillaris endothelium. Their permeabilities were calculated based on the physical theories and experimental material and permeability studies in the literature, which were used to describe diffusional hindrance in specific environments.
resultsOur compartmental BRB model predicts permeabilities with magnitudes similar to the experimental values in the literature. However, due to the small number and varying experimental conditions there is a large variability in the available experimental data, rendering validation of the model difficult. The model suggests that the paracellular pathway of the RPE largely defines the total BRB permeability.
conclusionsOur model is the first BRB model of its level and combines the present knowledge of the BRB barrier function. Furthermore, the model forms a platform for the future model development to be used for the design of new drugs and drug administration systems.
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Registered trials
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