ArticleDigestive diseases and sciences2015
Hypotension in the first week of acute pancreatitis and APACHE II score predict development of infected pancreatic necrosis.
Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 39 citations in OpenAlex.
- Association between the Fibrosis-4 index and mortality risk in acute pancreatitis.Frontiers in medicine · 2026Article
- Acute pancreatitis: Translating early mechanisms to bedside management.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
- Development and validation of a nomogram for predicting 30-day mortality in patients with severe acute pancreatitis and pneumonia.Scientific reports · 2025Article
- Risk factors for peripancreatic and pancreatic infection of acute pancreatitis and the development of a clinical prediction model.Medicine · 2025Observational
- Constructing a prediction model for acute pancreatitis severity based on liquid neural network.Scientific reports · 2025Article
- Contemporary Approach to Acute Pancreatitis in Emergency Medicine.Journal of the American College of Emergency Physicians open · 2025Review
- Early clinical predictors of infected pancreatic necrosis: a multicentre cohort study.eGastroenterology · 2024Article
- Trypsin and Trypsinogen Activation Peptide in the Prediction of Severity of Acute Pancreatitis.Life (Basel, Switzerland) · 2024Article
- Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis.Journal of translational medicine · 2024Article
- Receptor-Interacting Protein Kinase 3 as a Serological Biomarker in Relation to Disease Severity and Delirium After Acute Pancreatitis: A Prospective Cohort Study.International journal of general medicine · 2024Article
- Risk Factors and Prediction of 28-Day-All Cause Mortality Among Critically Ill Patients with Acute Pancreatitis Using Machine Learning Techniques: A Retrospective Analysis of Multi-Institutions.Journal of inflammation research · 2024Article
- Prediction of infected pancreatic necrosis in acute necrotizing pancreatitis by the modified pancreatitis activity scoring system.United European gastroenterology journal · 2023Article
- Development and validation of a nomogram for predicting survival in patients with acute pancreatitis.World journal of emergency medicine · 2023Article
- The Evaluation of Inflammatory Biomarkers in Predicting Progression of Acute Pancreatitis to Pancreatic Necrosis: A Diagnostic Test Accuracy Review.Healthcare (Basel, Switzerland) · 2022Review
- Article
- Effect ofFrontiers in physiology · 2020Article
- Antibacterial and Antifungal Therapy for Patients with Acute Pancreatitis at High Risk of Pancreatogenic Sepsis (Review).Sovremennye tekhnologii v meditsine · 2020Review
- Organ Failure Due to Systemic Injury in Acute Pancreatitis.Gastroenterology · 2019Review
- New Risk Factors for Infected Pancreatic Necrosis Secondary to Severe Acute Pancreatitis: The Role of Initial Contrast-Enhanced Computed Tomography.Digestive diseases and sciences · 2019Article
- 2019 WSES guidelines for the management of severe acute pancreatitis.World journal of emergency surgery : WJES · 2019Review
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHypotension and intestinal mucosal ischemia lead to bacterial translocation from the gut lumen into systemic circulation.
aimThe purpose of this study was to determine the strength of association between different types of organ failure (OF): hypotension (cardiovascular system failure), renal failure, respiratory failure, CNS failure and coagulopathy in the first week of acute pancreatitis (AP) and the subsequent development of infected pancreatic necrosis (IN).
methodsConsecutive patients with AP were evaluated for OF and its severity in the first week of hospital admission. Modified multiple organ failure score (MOFS) was used to identify and grade severity of OF. MOFS of ≥2, lasting for more than 48 h was defined as OF. Occurrence of IN (isolation of bacteria in necrosectomy specimen or image guided fine needle aspiration of pancreatic necrosis) was compared between groups with and without OF.
resultsOf the 81 patients, mean age was 40.1 ± 14.4 years and 55 were males; 60 (74 %) patients had OF and 13 (16 %) patients had IN. Occurrence of IN was not significantly different between patients with OF (18.3 %) and without OF (14.3 %), p = 0.48. However IN occurred in 10 % of patients without and 33.7 % patients with hypotension, p = 0.01. The rest of the organ systems analyzed did not show any significant difference in occurrence of infected necrosis. On multivariate analysis independent predictors of occurrence of IN were hypotension (odds ratio, OR 2.5, p < 0.001) and APACHE II score at 24 h of hospital admission (OR 4.77, p < 0.001).
conclusionHypotension in the first week of AP and APACHE II score predict development of IN.
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