ReviewCurrent atherosclerosis reports2014
Dissecting the causal genetic mechanisms of coronary heart disease.
Review in Current atherosclerosis reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- CYP4V2 rs56413992 C > T was associated with the risk of coronary heart disease in the Chinese Han population: a case-control study.BMC medical genomics · 2023Article
- Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease.Communications biology · 2022Article
- Haplotype-based genome-wide association studies for carcass and growth traits in chicken.Poultry science · 2020Article
- Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease.Disease markers · 2019Article
- Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus.PLoS genetics · 2018Article
- TCF21 is related to testis growth and development in broiler chickens.Genetics, selection, evolution : GSE · 2017Article
- Genome-Wide Association Studies Candidate Gene to Dual Modifier of Nonalcoholic Steatohepatitis and Atherosclerosis.JACC. Basic to translational science · 2016Article
- Genetics and Genomics of Coronary Artery Disease.Current cardiology reports · 2016Review
- Exome-Wide Association Analysis of Coronary Artery Disease in the Kingdom of Saudi Arabia Population.PloS one · 2016Article
- Cholesterol confusion and statin controversy.World journal of cardiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Large-scale genome-wide association studies (GWAS) have identified 46 loci that are associated with coronary heart disease (CHD). Additionally, 104 independent candidate variants (false discovery rate of 5 %) have been identified (Schunkert H, Konig IR, Kathiresan S, Reilly MP, Assimes TL, Holm H et al. Nat Genet 43:333-8, 2011; Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR et al. Nat Genet 45:25-33, 2012; C4D Genetics Consortium. Nat Genet 43:339-44, 2011). The majority of the causal genes in these loci function independently of conventional risk factors. It is postulated that a number of the CHD-associated genes regulate basic processes in the vascular cells involved in atherosclerosis, and that study of the signaling pathways that are modulated in this cell type by causal regulatory variation will provide critical new insights for targeting the initiation and progression of disease. In this review, we will discuss the types of experimental approaches and data that are critical to understanding the molecular processes that underlie the disease risk at 9p21.3, TCF21, SORT1, and other CHD-associated loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.