ArticleAmerican journal of physiology. Renal physiology2014
Theoretical assessment of renal autoregulatory mechanisms.
Article in American journal of physiology. Renal physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Office Blood Pressure and Arteriolosclerosis in Biopsy-Proven Glomerulonephritis: Association With Renal Function Decline and Clinical Outcomes.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Quantitative Assessment of Biological Dynamics with Aggregate Data.Bulletin of mathematical biology · 2025Article
- Purinergic Receptor Activation Protects Glomerular Microvasculature from Increased Mechanical Stress in Angiotensin II-Induced Hypertension: A Modeling Study.International journal of molecular sciences · 2025Article
- Heterogeneous afferent arteriolopathy: a key concept for understanding blood pressure-dependent renal damage.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Modeling the interaction between tubuloglomerular feedback and myogenic mechanisms in the control of glomerular mechanics.Frontiers in physiology · 2024Article
- Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury: State of the Art and Perspectives.Journal of clinical medicine · 2022Review
- Sex-Specific Computational Models of Kidney Function in Patients With Diabetes.Frontiers in physiology · 2022Article
- Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Simulations of Glomerular Shear and Hoop Stresses in Diabetes, Hypertension, and Reduced Renal Mass using a Network Model of a Rat Glomerulus.Physiological reports · 2020Article
- Sex differences in solute transport along the nephrons: effects of NaAmerican journal of physiology. Renal physiology · 2020Article
- Sex-specific computational models for blood pressure regulation in the rat.American journal of physiology. Renal physiology · 2020Article
- Functional implications of the sex differences in transporter abundance along the rat nephron: modeling and analysis.American journal of physiology. Renal physiology · 2019Article
- Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling.American journal of physiology. Heart and circulatory physiology · 2019Article
- Sex-specific long-term blood pressure regulation: Modeling and analysis.Computers in biology and medicine · 2019Article
- Functional implications of sexual dimorphism of transporter patterns along the rat proximal tubule: modeling and analysis.American journal of physiology. Renal physiology · 2018Article
- Renal medullary and urinary oxygen tension during cardiopulmonary bypass in the rat.Mathematical medicine and biology : a journal of the IMA · 2017Article
- Transfer Function Analysis of Dynamic Blood Flow Control in the Rat Kidney.Bulletin of mathematical biology · 2016Article
- Conduction of feedback-mediated signal in a computational model of coupled nephrons.Mathematical medicine and biology : a journal of the IMA · 2016Article
- Using mathematical models to understand metabolism, genes, and disease.BMC biology · 2015Article
- Mathematical modeling of renal hemodynamics in physiology and pathophysiology.Mathematical biosciences · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A mathematical model of renal hemodynamics was used to assess the individual contributions of the tubuloglomerular feedback (TGF) mechanism and the myogenic response to glomerular filtration rate regulation in the rat kidney. The model represents an afferent arteriole segment, glomerular filtration, and a short loop of Henle. The afferent arteriole model exhibits myogenic response, which is activated by hydrostatic pressure variations to induce changes in membrane potential and vascular muscle tone. The tubule model predicts tubular fluid and Cl(-) transport. Macula densa Cl(-) concentration is sensed as the signal for TGF, which acts to constrict or dilate the afferent arteriole. With this configuration, the model afferent arteriole maintains stable glomerular filtration rate within a physiologic range of perfusion pressure (80-180 mmHg). The contribution of TGF to overall autoregulation is significant only within a narrow band of perfusion pressure values (80-110 mmHg). Model simulations of ramp-like perfusion pressure perturbations agree well with findings by Flemming et al. (Flemming B, Arenz N, Seeliger E, Wronski T, Steer K, Persson PB. J Am Soc Nephrol 12: 2253-2262, 2001), which indicate that changes in vascular conductance are markedly sensitive to pressure velocity. That asymmetric response is attributed to the rate-dependent kinetics of the myogenic mechanism. Moreover, simulations of renal autoregulation in diabetes mellitus predict that, due to the impairment of the voltage-gated Ca(2+) channels of the afferent arteriole smooth muscle cells, the perfusion pressure range in which single-nephron glomerular filtration rate remains stable is reduced by ~70% and that TGF gain is reduced by nearly 40%, consistent with experimental findings.
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