ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2014
The frontoparietal control system: a central role in mental health.
Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 256 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
256 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Common neural dysfunction in psychiatric disorders: Insights from a meta-analysis of resting-state fMRI studies.Translational psychiatry · 2025Pooled it
- Human neural correlates of emotional well-being (EWB): a preliminary systematic review and meta-analysis of MRI studies based on a recent consensus definition.Frontiers in human neuroscience · 2025Pooled it
- Pooled it
- Reduced Brain Gray Matter Volume in Patients With First-Episode Major Depressive Disorder: A Quantitative Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- The neural basis of motivational influences on cognitive control.Human brain mapping · 2018Pooled it
- A domain-general brain network underlying emotional and cognitive interference processing: evidence from coordinate-based and functional connectivity meta-analyses.Brain structure & function · 2018Pooled it
- Comparative efficacy of dual- vs. single-node tACS in amnestic mild cognitive impairment: behavioral and EEG evidence.Translational psychiatry · 2026Trial
- Peripheral miRNA profiling identifies therapy-specific biological trajectories in the treatment of cognitive dysfunction in depression: an exploratory mechanistic study.Scientific reports · 2026Trial
- Investigating Social Competence in a Pilot Randomized Clinical Trial of a Theatre-Based Intervention Enhanced for Adults with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2025Trial
- Multilevel growth curve analyses of behavioral activation for anhedonia (BATA) and mindfulness-based cognitive therapy effects on anhedonia and resting-state functional connectivity: Interim results of a randomized trialJournal of affective disorders · 2021Trial
- Functional connectivity changes associated with fMRI neurofeedback of right inferior frontal cortex in adolescents with ADHD.NeuroImage · 2019Trial
- An experimental test of the fetal programming hypothesis: Can we reduce child ontogenetic vulnerability to psychopathology by decreasing maternal depression?Development and psychopathology · 2018Trial
- Prefrontal mediation of the reading network predicts intervention response in dyslexia.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Trial
- Exploring Psychopathology with Brain Fingerprinting Technique.Annals of neurosciences · 2026Article
- Subtyping Internet Gaming Disorder Based on Interindividual Deviation of Functional Connectivity: A Network Contingency Analysis.Addiction biology · 2026Article
- Enhancing resilience, flexibility, and well-being through cognitive-emotional training: behavioral and neural evidence.Scientific reports · 2026Article
- Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.Nature communications · 2026Article
- Adolescents' Strategies to Manage Mental Health Challenges In and After the Pandemic: Two Mixed-Methods Studies.Research on child and adolescent psychopathology · 2026Article
- The cerebral neurovascular coupling and glymphatic circulation dysfunction in children with attention deficit/hyperactivity disorder.BMC psychiatry · 2026Article
- Review
196 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Recent findings suggest the existence of a frontoparietal control system consisting of flexible hubs that regulate distributed systems (e.g., visual, limbic, motor) according to current task goals. A growing number of studies are reporting alterations of this control system across a striking range of mental diseases. We suggest this may reflect a critical role for the control system in promoting and maintaining mental health. Specifically, we propose that this system implements feedback control to regulate symptoms as they arise (e.g., excessive anxiety reduced via regulation of amygdala), such that an intact control system is protective against a variety of mental illnesses. Consistent with this possibility, recent results indicate that several major mental illnesses involve altered brain-wide connectivity of the control system, likely altering its ability to regulate symptoms. These results suggest that this "immune system of the mind" may be an especially important target for future basic and clinical research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.