ArticleThe lancet. Diabetes & endocrinology2014
Mechanisms of changes in glucose metabolism and bodyweight after bariatric surgery.
Article in The lancet. Diabetes & endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 147 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Semaglutide 2.4mg for Low Responders After Bariatric Surgery
Effects of Hepatic Insulin Resistance on Type 2 Diabetes Mellitus in Morbidly Obese Subjects Following Roux-en-Y Gastric Bypass Surgery or Gastric Sleeve Surgery
Changes in the Intestinal and Oral Microbiome of Morbidly Obese Patients Undergoing Gastric Bypass Surgery in Relation to Insulin Resistance and Metabolic Syndrome
Who cites it
147 citing papers in PubMed, 4 syntheses or guidelines pooled it, 298 citations in OpenAlex.
- Efficacy of Endoscopic Sutured Gastroplasty on Diabetes Mellitus Type 2-A Systematic Review.Endocrinology, diabetes & metabolism · 2025Pooled it
- Metabolic aspects of surgical subcutaneous fat removal: An umbrella review and implications for future research.Biomolecules & biomedicine · 2023Pooled it
- Metabolic Surgery and Diabesity: a Systematic Review.Obesity surgery · 2018Pooled it
- Pooled it
- Trial
- Altered postprandial glucose metabolism and enteropancreatic hormone responses during pregnancy following Roux-en-Y gastric bypass: a prospective cohort study.BMJ open diabetes research & care · 2025Trial
- Effects of physical form ofThe British journal of nutrition · 2024Trial
- Comparable Effects of Sleeve Gastrectomy and Roux-en-Y Gastric Bypass on Basal Fuel Metabolism and Insulin Sensitivity in Individuals with Obesity and Type 2 Diabetes.Journal of diabetes research · 2022Trial
- Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass.Frontiers in endocrinology · 2021 · on this mapTrial
- Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass.Physiological reports · 2017Trial
- Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery.International journal of obesity (2005) · 2016Trial
- Effects of RYGB on energy expenditure, appetite and glycaemic control: a randomized controlled clinical trial.International journal of obesity (2005) · 2016Trial
- Metabolic and biochemical predictors of glycemic response after bariatric surgery: a scoping review.Updates in surgery · 2026Review
- Biological functions and emerging interplay of FGF21 and GDF15 in metabolic diseases and aging.Molecular biomedicine · 2026Review
- Interplay Between the Gut Microbiome and Oxidative Stress in Type 2 Diabetes.Antioxidants (Basel, Switzerland) · 2026Review
- Low Preoperative Free Triiodothyronine, Particularly in Females, Is Associated With Reduced Weight Loss and Diabetes Remission After Bariatric Surgery in Euthyroid Adults.Diabetes/metabolism research and reviews · 2026Article
- Glycemic Normalization Immediately Following Vertical Sleeve Gastrectomy in Adolescents With Type 2 Diabetes From the STDiabetes, obesity & metabolism · 2026Article
- Impact of sleeve gastrectomy on the course of metabolic associated fatty liver disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Observational
- Safety and efficacy of laparoscopic sleeve gastrectomy in adolescents with Grade V obesity (BMI ≥ 50 kg/mClinics (Sao Paulo, Brazil) · 2026Article
- Effects of Gastric Bypass on Beta-cell function and Insulin sensitivity in Patients with Non-Severe Obesity (BMI<35 kg/mObesity surgery · 2026Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bariatric surgery is the most effective treatment for obesity and also greatly improves glycaemic control, often within days after surgery, independently of weight loss. Laparoscopic adjustable gastric banding (LAGB) was designed as a purely restrictive procedure, whereas vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) induce changes in appetite through regulation of gut hormones, resulting in decreased hunger and increased satiation. Thus, VSG and RYBG more frequently result in remission of type 2 diabetes than does LAGB. With all three of these procedures, remission of diabetes is associated with early increases in insulin sensitivity in the liver and later in peripheral tissues; VSG and RYBG are also associated with improved insulin secretion and an exaggerated postprandial rise in glucagon-like peptide 1. The vagal pathway could have a role in the neurohumoral regulatory pathways that control appetite and glucose metabolism after bariatric surgery. Recent research suggests that changes in bile acid concentrations in the blood and altered intestinal microbiota might contribute to metabolic changes after surgery, but the mechanisms are unclear. In this Series paper, we explore the possible mechanisms underlying the effects on glucose metabolism and bodyweight of LAGB, VSG, and RYGB surgery. Elucidation of these mechanisms is providing knowledge about bodyweight regulation and the pathophysiology of type 2 diabetes, and could help to identify new drug targets and improved surgical techniques.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.