Evidence map›Paper›PMID 24622617›Full record

ReviewNature reviews. Molecular cell biology2014

Realizing the potential of synthetic biology.

George M Church, Michael B Elowitz, Christina D Smolke, Christopher A Voigt, Ron Weiss

Abstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. A Genetic Circuit Design for Targeted Viral RNA Degradation.Bioengineering (Basel, Switzerland) · 2023
    Article
  15. Review
  16. Regulation strategies for two-output biomolecular networks.Journal of the Royal Society, Interface · 2023
    Article
  17. Article
  18. The Systems and Synthetic Biology of Auxin.Cold Spring Harbor perspectives in biology · 2022
    Review
  19. Review
  20. Synthetic biology landscape and community in Germany.Biotechnology notes (Amsterdam, Netherlands) · 2022
    Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

George M ChurchDepartment of Genetics, Harvard Medical School, Harvard University, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
Michael B ElowitzDivision of Biology and Biological Engineering and Department of Applied Physics, Howard Hughes Medical Institute, California Institute of Technology (Caltech), M/C 114-96, Pasadena, California 91125, USA.
Christina D SmolkeStanford University School of Medicine, 473 Via Ortega, University of Stanford, Stanford, California 94305, USA.
Christopher A VoigtSynthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology (MIT), 500 Technology Square, Cambridge, Massachusetts 02139, USA.
Ron WeissSynthetic Biology Center, Department of Biological Engineering, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), NE47-223, 500 Technology Square, Cambridge, Massachusetts 02139, USA.

Funding

Synthetic Biology Platforms for Natural Product Discovery and BiosynthesisDP1AT007886 · NCCIH · STANFORD UNIVERSITY · PI SMOLKE, CHRISTINA D · 2012 to 2016
$3.9M
Frameworks for programming ligand-responsive RNA regulatory systemsR01GM086663 · NIGMS · STANFORD UNIVERSITY · PI ENDY, DREW · 2009 to 2024
$3.7M
NCCIH NIH HHS DP1 AT007886NIGMS NIH HHS R01 GM086663
6 · The paper itself

Abstract

Synthetic biology, despite still being in its infancy, is increasingly providing valuable information for applications in the clinic, the biotechnology industry and in basic molecular research. Both its unique potential and the challenges it presents have brought together the expertise of an eclectic group of scientists, from cell biologists to engineers. In this Viewpoint article, five experts discuss their views on the future of synthetic biology, on its main achievements in basic and applied science, and on the bioethical issues that are associated with the design of new biological systems.

Indexed as

BiotechnologyGenetic EngineeringSystems BiologyGuidelines as TopicHumansSynthetic Biology

Identifiers

PMID24622617
PMCPMC9645560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.