Evidence map›Paper›PMID 24622610›Full record

Observational studyJournal of the American Heart Association2014

History of gestational diabetes mellitus and future risk of atherosclerosis in mid-life: the Coronary Artery Risk Development in Young Adults study.

Erica P Gunderson, Vicky Chiang, Mark J Pletcher, David R Jacobs, Charles P Quesenberry, Stephen Sidney, Cora E Lewis

2 registry-linked trialsOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 114 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 5 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03607799 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

A Culturally-tailored Personalized Nutrition Intervention in South Asian Women at Risk of Gestational Diabetes Mellitus

TypeinterventionalSponsorMcMaster UniversityRan2020 to 2025Enrolled140ConditionsDiabetes, GestationalArmsDietary Intervention, Control
NCT04801121 unknown statusnot on this mapstarted 2020, after this paper: background citation

Fetal Growth and Placental Function in Pregnancies Complicated by Diabetes

Typeobservational_patient_registrySponsorSidsel Linneberg RathckeRan2020 to 2023Enrolled100ConditionsPregnancy in Diabetics, Placenta, Fetal Growth, Magnetic Resonance Imaging
3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 5 syntheses or guidelines pooled it, 180 citations in OpenAlex.

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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Erica P GundersonDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Vicky Chiang
Mark J Pletcher
David R Jacobs
Charles P Quesenberry
Stephen Sidney
Cora E Lewis
Kaiser Permanente · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Minnesota · US

Funding

Lactation and Glucose Tolerance After GDM PregnancyR01HD050625 · NICHD · KAISER FOUNDATION RESEARCH INSTITUTE · PI GUNDERSON, ERICA PAULINE · 2007 to 2011
$3.1M
Lactation and Incidence of Diabetes Mellitus in CARDIA WomenR01DK090047 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GUNDERSON, ERICA PAULINE · 2011 to 2014
$2.7M
Pregnancy and Risk Factors for CVD and Type 2 DiabetesK01DK059944 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GUNDERSON, ERICA PAULINE · 2002 to 2006
$640k
STUDY CORONARY HEART DISEASE RISK IN YOUNG ADULTSN01HC048050 · HC · KAISER FOUNDATION RESEARCH INSTITUTE · PI SIDNEY, STEPHEN · 1985 to 2000
$102k
Intramural NIH HHSNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNICHD NIH HHS R01 HD050625NIDDK NIH HHS K01 DK059944NIDDK NIH HHS R01 DK090047
6 · The paper itself

Abstract

backgroundHistory of gestational diabetes mellitus (GDM) increases lifetime risk of type 2 diabetes (DM) and the metabolic syndrome (MetS), which increase risk of cardiovascular disease. It is unclear, however, whether GDM increases risk of early atherosclerosis independent of pre-pregnancy obesity and subsequent metabolic disease. METHODS AND

resultsOf 2787 women (18 to 30 years) enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study, we studied 898 (47% black) who were free of DM and heart disease at baseline (1985-1986), delivered ≥1 post-baseline births, reported GDM history, and had common carotid intima media thickness (ccIMT, mm) measured in 2005-2006. We used multivariable linear regression to assess associations between GDM and ccIMT adjusted for race, age, parity, and pre-pregnancy cardiometabolic risk factors. We assessed mediators (weight gain, insulin resistance, blood pressure), and effect modification by incident DM or MetS during the 20-year period. Of the 898 women, 119 (13%) reported GDM (7.6 per 100 deliveries). Average age was 31 at last birth and 44 at ccIMT measurement for GDM and non-GDM groups. Unadjusted mean ccIMT was 0.023 mm higher for GDM than non-GDM groups (P=0.029), but pre-pregnancy BMI attenuated the difference to 0.016 mm (P=0.109). In 777 women without subsequent DM or the MetS, mean ccIMT was 0.023 mm higher for GDM versus non-GDM groups controlling for race, age, parity, and pre-pregnancy BMI (0.784 versus 0.761, P=0.039). Addition of pre-pregnancy insulin resistance index had minimal impact on adjusted mean net ccIMT difference (0.22 mm). Mean ccIMT did not differ by GDM status among 121 women who developed DM or the MetS (P=0.58).

conclusionsHistory of GDM may be a marker for early atherosclerosis independent of pre-pregnancy obesity among women who have not developed type 2 diabetes or the metabolic syndrome.

Indexed as

AdolescentAdultAge FactorsCarotid Artery DiseasesCarotid Intima-Media ThicknessChi-Square DistributionCoronary Artery DiseaseDiabetes, GestationalFemaleHumansLinear ModelsLongitudinal StudiesMultivariate AnalysisObesityPregnancyPrognosisatherosclerosisgestational diabetes mellituspregnancyprospective cohort studieswomen

Identifiers

PMID24622610
PMCPMC4187501
OpenAlexW2128511294

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.