Trial reportPloS one2014
Cardiopulmonary fitness correlates with regional cerebral grey matter perfusion and density in men with coronary artery disease.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Higher VOScientific reports · 2021Trial
- Brain Perfusion Change in Patients with Mild Cognitive Impairment After 12 Months of Aerobic Exercise Training.Journal of Alzheimer's disease : JAD · 2020Trial
- Decreases in body mass index after cardiac rehabilitation predict improved cognitive function in older adults with heart failure.Journal of the American Geriatrics Society · 2014Trial
- Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease.GeroScience · 2026Article
- Article
- Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy.Journal of psychiatry & neuroscience : JPN · 2021Article
- Cardiorespiratory fitness is associated with increased middle cerebral arterial compliance and decreased cerebral blood flow in young healthy adults: A pulsed ASL MRI study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Lifestyle and neurodegeneration in midlife as expressed on functional magnetic resonance imaging: A systematic review.Alzheimer's & dementia (New York, N. Y.) · 2018Review
- A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology.Journal of Alzheimer's disease : JAD · 2018Article
- Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline.AJNR. American journal of neuroradiology · 2015Review
- [Stress and optimal ageing].Zeitschrift fur Gerontologie und Geriatrie · 2015Article
- Exercise intensity modulates the change in cerebral blood flow following aerobic exercise in chronic stroke.Experimental brain research · 2015Article
- Decreases in daily physical activity predict acute decline in attention and executive function in heart failure.Journal of cardiac failure · 2015Article
- Regional cerebral arterial transit time hemodynamics correlate with vascular risk factors and cognitive function in men with coronary artery disease.AJNR. American journal of neuroradiology · 2015Article
- Impaired Cerebrovascular Function in Coronary Artery Disease Patients and Recovery Following Cardiac Rehabilitation.Frontiers in aging neuroscience · 2015Article
- The Effects of Aerobic Exercise on Cognitive and Neural Decline in Aging and Cardiovascular Disease.Current geriatrics reports · 2014Article
- Influence of central nervous system-acting drugs on results of cognitive testing in geriatric inpatients.Zeitschrift fur Gerontologie und Geriatrie · 2014Article
- COPD is associated with cognitive dysfunction and poor physical fitness in heart failure.Heart & lung : the journal of critical careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
purposePhysical activity is associated with positive effects on the brain but there is a paucity of clinical neuroimaging data in patients with coronary artery disease (CAD), a cardiovascular condition associated with grey matter loss. The purpose of this study was to determine which brain regions are impacted by cardiopulmonary fitness and with the change in fitness after 6 months of exercise-based cardiac rehabilitation.
methodsCAD patients underwent magnetic resonance imaging at baseline, and peak volume of oxygen uptake during exercise testing (VO2Peak) was measured at baseline and after 6 months of training. T1-weighted structural images were used to perform grey matter (GM) voxel-based morphometry (VBM). Pseudo-continuous arterial spin labeling (pcASL) was used to produce cerebral blood flow (CBF) images. VBM and CBF data were tested voxel-wise using VO2Peak and age as explanatory variables.
resultsIn 30 men with CAD (mean age 65±7 years), VBM and CBF identified 7 and 5 respective regions positively associated with baseline VO2Peak. These included the pre- and post-central, paracingulate, caudate, hippocampal regions and converging findings in the putamen. VO2Peak increased by 20% at follow-up in 29 patients (t = 9.6, df = 28, p<0.0001). Baseline CBF in the left post-central gyrus and baseline GM density in the right putamen predicted greater change in VO2Peak.
conclusionPerfusion and GM density were associated with fitness at baseline and with greater fitness gains with exercise. This study identifies new neurobiological correlates of fitness and demonstrates the utility of multi-modal MRI to evaluate the effects of exercise in CAD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.