ArticleCirculation. Cardiovascular genetics2014
NOS1 methylation and carotid artery intima-media thickness in children.
Article in Circulation. Cardiovascular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Review
- Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis.Environmental science and pollution research international · 2021Review
- Targeting Epigenetics and Non-coding RNAs in Myocardial Infarction: From Mechanisms to Therapeutics.Frontiers in genetics · 2021Review
- Nitric Oxide Synthase Type 1 Methylation Is Associated With White Matter Microstructure in the Corpus Callosum and Greater Panic Disorder Severity Among Panic Disorder Patients.Frontiers in neurology · 2021Article
- Maternal and gestational influences on childhood blood pressure.Pediatric nephrology (Berlin, Germany) · 2020Article
- Exercise, redox homeostasis and the epigenetic landscape.Redox biology · 2020Review
- SHIP-AHOY (Study of High Blood Pressure in Pediatrics: Adult Hypertension Onset in Youth).Hypertension (Dallas, Tex. : 1979) · 2018Article
- Hypomethylation of Interleukin-6 Promoter is Associated with the Risk of Coronary Heart Disease.Arquivos brasileiros de cardiologia · 2016Article
- Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity.International journal of molecular sciences · 2015Article
- Recent clinical and translational advances in pediatric hypertension.Hypertension (Dallas, Tex. : 1979) · 2015Review
- Epigenetic reprogramming in atherosclerosis.Current atherosclerosis reports · 2015Review
- Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk.Clinical epigenetics · 2015Article
- Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population.International journal of molecular sciences · 2014Article
- Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men.Clinical epigenetics · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNitric oxide (NO) plays an important role in cardiovascular health by maintaining and regulating vascular tone and blood flow. Epigenetic regulation of NO synthase (NOS), the genes responsible for NO production, may affect cardiovascular disease, including the development of atherosclerosis in children. METHODS AND
resultsWe measured percentage DNA methylation using bisulfite conversion and pyrosequencing assays on DNA from buccal cells provided by 377 participants of the Children's Health Study on whom carotid artery intima-media thickness (CIMT) measurements were also collected. We examined a total of 16 CpG loci located within NOS1, NOS2A, NOS3, ARG1, and ARG2 genes responsible for NO production. CIMT was measured using high-resolution B-mode carotid ultrasound. The association between percentage DNA methylation in ARG and NOS genes with CIMT was evaluated using linear regression adjusted for sex, ethnicity, body mass index, age at CIMT, town of residence, and experimental plate for pyrosequencing reactions. Differences in the association by ethnicity and ancestral group were also evaluated. For a 1% increase in average DNA methylation of NOS1, CIMT increased by 1.2 μm (P=0.02). This association was greater in Hispanic children of Native American descent (β=2.3; P=0.004) than in non-Hispanic whites (β=0.3; P=0.71) or Hispanic whites (β=1.0; P=0.35).
conclusionsDNA methylation of NOS1 has a plausible role in atherogenesis through regulation of NO production, although ancestry may alter the magnitude of this association.
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