ArticlePloS one2014
Personality, behavior and environmental features associated with OXTR genetic variants in British mothers.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Oxytocin response to food intake in avoidant/restrictive food intake disorder.European journal of endocrinology · 2023Article
- A prolonged latent phase: An early career in oxytocin during birth.Comprehensive psychoneuroendocrinology · 2023Article
- Loneliness in pregnant and postpartum people and parents of children aged 5 years or younger: a scoping review.Systematic reviews · 2022Article
- Review of eating disorders and oxytocin receptor polymorphisms.Journal of eating disorders · 2021Review
- Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood.Nutrition research (New York, N.Y.) · 2021Article
- Understanding loneliness in the twenty-first century: an update on correlates, risk factors, and potential solutions.Social psychiatry and psychiatric epidemiology · 2020Review
- A SNP, Gene, and Polygenic Risk Score Approach of Oxytocin-Vasopressin Genes in Adolescents' Loneliness.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2020Article
- Data Resource Profile: The ALSPAC birth cohort as a platform to study the relationship of environment and health and social factors.International journal of epidemiology · 2019Article
- The Neuropeptide Hormone Oxytocin in Eating Disorders.Current psychiatry reports · 2018Review
- The effects of oxytocin on eating behaviour and metabolism in humans.Nature reviews. Endocrinology · 2017Review
- Polymorphisms of the oxytocin receptor gene and overeating: the intermediary role of endophenotypic risk factors.Nutrition & diabetes · 2017Article
- Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Association Between Oxytocin Receptor Genotype, Maternal Care, and Eating Disorder Behaviours in a Community Sample of Women.European eating disorders review : the journal of the Eating Disorders Association · 2017Article
- Polymorphisms of two loci at the oxytocin receptor gene in populations of Africa, Asia and South Europe.BMC genetics · 2016Article
- Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa.Psychiatry research · 2015Article
- Interaction between oxytocin receptor DNA methylation and genotype is associated with risk of postpartum depression in women without depression in pregnancy.Frontiers in genetics · 2015Article
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9 authors.
Funding
Abstract
backgroundIt is assumed that the oxytocin receptor gene (OXTR) is associated with factors that are related to features of reproduction as well as the currently emerging fields of mood and emotional response.
methodsWe analysed data from over 8000 mothers who participated in the Avon Longitudinal Study of Parents and Children (ALSPAC). We determined reproductive, emotional and personality differences related to the two SNPs rs53576 and rs2254298 of the oxytocin receptor gene to determine whether there was evidence in this population for: (i) associations with emotional and personality differences, and (ii) behavioural or environmental links with these SNPs using a hypothesis free approach with over 1000 types of exposure.
resultsOur analyses of 7723 women showed that there were no differences in 11 mood, social or relationship characteristics associated with the rs2254298, and just one with rs53576 (with emotional loneliness)--one statistically significant out of 22 tests is no more than would be expected by chance. There were no interactions with childhood abuse. Using a hypothesis-free approach we found few indicators of environmental or behavioural differences associated with rs2254298, but there was an excess of associations with eating habits with rs53576. The findings included an association with dieting to lose weight, and habits typical of bulimia for the women with GG. The nutrition of the women also showed negative associations of the GG genotype with 13 nutrients, including vitamins D, B12 and retinol, and intake of calcium, potassium and iodine.
conclusionsWe conclude that this large database of pregnant women was unable to provide confirmation of the types of personality associated with these two OXTR SNPs, but we have shown some evidence of eating differences in those with GG on rs53576. Confirmation of our hypothesis free associations using other data sets is important.
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