ArticlePloS one2014
Hip fractures and bone mineral density in the elderly--importance of serum 25-hydroxyvitamin D.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The impact of COVID-19 on mortality in trauma patients undergoing orthopedic surgery: a systematic review and meta-analysis.Clinical and experimental emergency medicine · 2023Pooled it
- Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis.Journal of bone and mineral metabolism · 2022Pooled it
- The relationship between serum vitamin D and fracture risk in the elderly: a meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies.Oncotarget · 2017Pooled it
- The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- An exploration of serum 25-hydroxyvitamin D levels after unstable femoral intertrochanteric fractures in community-dwelling elderly.Saudi medical journal · 2025Article
- Frequency of Osteoporosis-Related Fractures in the Kingdom of Bahrain.Healthcare (Basel, Switzerland) · 2024Article
- Milk intake and hip fracture incidence in community-dwelling old Icelandic adults.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Scientific opinion on the tolerable upper intake level for vitamin D, including the derivation of a conversion factor for calcidiol monohydrate.EFSA journal. European Food Safety Authority · 2023Article
- Absence of causal association between Vitamin D and bone mineral density across the lifespan: a Mendelian randomization study.Scientific reports · 2022Article
- A genome-wide association study of serum proteins reveals shared loci with common diseases.Nature communications · 2022Article
- Does the relationship between 25-hydroxyvitamin D status and bone mass vary according to skin color in adults? Results of a Brazilian population-based study.Archives of osteoporosis · 2021Article
- Characteristics of incidence hip fracture cases in older adults participating in the longitudinal AGES-Reykjavik study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Epidemiology of the association between serum 25-hydroxyvitamin D levels and musculoskeletal conditions among elderly individuals: a literature review.Journal of physiological anthropology · 2020Review
- Papillary thyroid carcinoma is a risk factor for severe osteoporosis.Journal of bone and mineral metabolism · 2020Article
- Analysis of Related Factors of Brittle Hip Fracture in Postmenopausal Women with Osteoporosis.Orthopaedic surgery · 2020Article
- Type 2 diabetes and obesity in midlife and breast cancer risk in the Reykjavik cohort.Cancer causes & control : CCC · 2019Article
- The Paradoxical Role of Uric Acid in Osteoporosis.Nutrients · 2019Review
- Pre-diagnostic 25-hydroxyvitamin D levels and survival in cancer patients.Cancer causes & control : CCC · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundThe significance of serum 25-hydroxyvitamin D [25(OH)D] concentrations for hip fracture risk of the elderly is still uncertain. Difficulties reaching both frail and healthy elderly people in randomized controlled trials or large cohort studies may in part explain discordant findings. We determined hazard ratios for hip fractures of elderly men and women related to serum 25(OH)D, including both the frail and the healthy segment of the elderly population.
methodsThe AGES-Reykjavik Study is a prospective study of 5764 men and women, age 66-96 years, based on a representative sample of the population of Reykjavik, Iceland. Participation was 71.8%. Hazard ratios of incident hip fractures and baseline bone mineral density were determined according to serum concentrations of 25(OH)D at baseline.
resultsMean follow-up was 5.4 years. Compared with referent values (50-75 nmol/L), hazard ratios for hip fractures were 2.24 (95% CI 1.63, 3.09) for serum 25(OH)D <30 nmol/L, adjusting for age, sex, body mass index, height, smoking, alcohol intake and season, and 2.08 (95% CI 1.51, 2.87), adjusting additionally for physical activity. No difference in risk was associated with 30-50 nmol/L or ≥75 nmol/L in either model compared with referent. Analyzing the sexes separately, hazard ratios were 2.61 (95% CI 1.47, 4.64) in men and 1.93 (95% CI 1.31, 2.84) in women. Values <30 nmol/L were associated with significantly lower bone mineral density of femoral neck compared with referent, z-scores -0.14 (95% CI -0.27, -0.00) in men and -0.11 (95% CI -0.22, -0.01) in women.
conclusionsOur results lend support to the overarching importance of maintaining serum 25(OH)D above 30 nmol/L for bone health of elderly people while potential benefits of having much higher levels could not be detected.
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