Evidence map›Paper›PMID 24621476›Full record

ReviewCell adhesion & migration2014

Endothelial cell-cell adhesion during zebrafish vascular development.

Anne K Lagendijk, Alpha S Yap, Benjamin M Hogan

Open access · goldAbstract readReview
In one paragraph

Review in Cell adhesion & migration, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Anne K LagendijkInstitute for Molecular Bioscience; The University of Queensland;Brisbane, QLD, Australia.
Alpha S YapInstitute for Molecular Bioscience; The University of Queensland;Brisbane, QLD, Australia.
Benjamin M HoganInstitute for Molecular Bioscience; The University of Queensland;Brisbane, QLD, Australia.
Research Institute for Bioscience and Biotechnology · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vertebrate vasculature is an essential organ network with major roles in health and disease. The establishment of balanced cell-cell adhesion in the endothelium is crucial for the functionality of the vascular system. Furthermore, the correct patterning and integration of vascular endothelial cell-cell adhesion drives the morphogenesis of new vessels, and is thought to couple physical forces with signaling outcomes during development. Here, we review insights into this process that have come from studies in zebrafish. First, we describe mutants in which endothelial adhesion is perturbed, second we describe recent progress using in vivo cell biological approaches that allow the visualization of endothelial cell-cell junctions. These studies underline the profound potential of this model system to dissect in great detail the function of both known and novel regulators of endothelial cell-cell adhesion.

Indexed as

Adherens JunctionsAnimalsCadherinsCell AdhesionCytoskeletonEmbryonic DevelopmentEndothelium, VascularHumansNeovascularization, PhysiologicZebrafishCadherinsadherens junctionadhesionanastomosisangiogenesiscadherincytoskeletontime-lapsetransgenicvascularzebrafish

Identifiers

PMID24621476
PMCPMC4049859
OpenAlexW1965334304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.