SynthesisLipids in health and disease2014
Apolipoprotein E gene polymorphism and the risk of intracerebral hemorrhage: a meta-analysis of epidemiologic studies.
Synthesis in Lipids in health and disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The APOE paradox: divergent genetic influences on hemorrhagic stroke risk-A meta-analysis.Frontiers in stroke · 2026Pooled it
- Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions.Journal of the neurological sciences · 2019Pooled it
- Genetic susceptibility to cerebrovascular disease: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Pooled it
- Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction.PloS one · 2014Pooled it
- APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban.JAMA neurology · 2025Article
- The Role of Aging in Intracerebral Hemorrhage.Brain sciences · 2024Review
- Intracerebral Hemorrhage Genetics.Genes · 2022Review
- Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage.International journal of molecular sciences · 2022Review
- Genetics of Spontaneous Intracerebral Hemorrhage: Risk and Outcome.Frontiers in neuroscience · 2022Review
- Advances and challenges in quantitative delineation of the genetic architecture of complex traits.Quantitative biology (Beijing, China) · 2021Article
- Genetic Regulatory Networks of Apolipoproteins and Associated Medical Risks.Frontiers in cardiovascular medicine · 2021Review
- A Quarter Century of APOE and Alzheimer's Disease: Progress to Date and the Path Forward.Neuron · 2019Review
- Genetic Polymorphisms Associated with Spontaneous Intracerebral Hemorrhage.International journal of molecular sciences · 2018Review
- Absolute 10-year risk of dementia by age, sex andCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
- Racial/ethnic variation ofNeurology · 2018Article
- Genetic Insights into Cerebrovascular Disorders: A Comprehensive Review.Journal of vascular and interventional neurology · 2017Article
- ApoA1, ApoJ and ApoE Plasma Levels and Genotype Frequencies in Cerebral Amyloid Angiopathy.Neuromolecular medicine · 2016Article
- Genetic risk factors for spontaneous intracerebral haemorrhage.Nature reviews. Neurology · 2016Review
- Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population.Journal of molecular neuroscience : MN · 2015Article
- Statins in Intracerebral Hemorrhage.Current atherosclerosis reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies investigating the association between the apolipoprotein E (APOE) gene polymorphism and the risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship.
methodsPublished literature from the National Library of Medline and Embase databases were retrieved. Odds ratio (OR) and 95% confidence interval (CI) were calculated in fixed- or random-effects models when appropriate. Subgroup analyses were performed by race.
resultsThis meta-analysis included 11 case-control studies, which included 1,238 ICH cases and 3,575 controls. The combined results based on all studies showed that ICH cases had a significantly higher frequency of APOE ϵ4 allele (OR= 1.42, 95% CI= 1.21,1.67, P<0.001). In the subgroup analysis by race, we also found that ICH cases had a significantly higher frequency of APOE ϵ4 allele in Asians (OR= 1.52, 95% CI= 1.20,1.93, P<0.001) and in Caucasians (OR= 1.34, 95% CI= 1.07,1.66, P=0.009). There was no significant relationship between APOE ϵ2 allele and the risk of ICH.
conclusionOur meta-analysis suggested that APOE ϵ4 allele was associated with a higher risk of ICH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.