ArticleDiagnostic pathology2014
The expression and clinical significance of miR-132 in gastric cancer patients.
Article in Diagnostic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glutathione S-transferase M1 null genotype meta-analysis on gastric cancer risk.Diagnostic pathology · 2014Pooled it
- Review
- Observational
- MicroRNA-132 suppresses migration and invasion of renal carcinoma cells.Journal of clinical laboratory analysis · 2020Article
- LncRNA SNHG5 affects cell proliferation, metastasis and migration of colorectal cancer through regulating miR-132-3p/CREB5.Cancer biology & therapy · 2019Article
- Five serum-based miRNAs were identified as potential diagnostic biomarkers in gastric cardia adenocarcinoma.Cancer biomarkers : section A of Disease markers · 2018Article
- miR-132 and miR-212 cluster function as a tumor suppressor in thyroid cancer cells by CSDE1 mediated post-transcriptional program.International journal of clinical and experimental pathology · 2018Article
- Human thymic stromal lymphopoietin promotes the proliferation and invasion of cervical cancer cells by downregulating microRNA-132 expression.Oncology letters · 2017Article
- Prognostic value of microRNAs in gastric cancer: a meta-analysis.Oncotarget · 2017Article
- Epigenetic modulation associated with carcinogenesis and prognosis of human gastric cancer.Oncology letters · 2017Article
- Downregulation of microRNA-132 indicates progression in hepatocellular carcinoma.Experimental and therapeutic medicine · 2016Article
- MicroRNA-132 targets PEA-15 and suppresses the progression of astrocytoma in vitro.Journal of neuro-oncology · 2016Article
- MicroRNAs in glioblastoma multiforme pathogenesis and therapeutics.Cancer medicine · 2016Review
- An Encapsulation of Gene Signatures for Hepatocellular Carcinoma, MicroRNA-132 Predicted Target Genes and the Corresponding Overlaps.PloS one · 2016Article
- MicroRNA-132 inhibits cell growth and metastasis in osteosarcoma cell lines possibly by targeting Sox4.International journal of oncology · 2015Article
- Recent advances in the molecular diagnostics of gastric cancer.World journal of gastroenterology · 2015Review
- MicroRNA-212 functions as an epigenetic-silenced tumor suppressor involving in tumor metastasis and invasion of gastric cancer through down-regulating PXN expression.American journal of cancer research · 2015Article
- Upregulation of miR-132 expression in glioma and its clinical significance.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Decreased microRNA-224 and its clinical significance in non-small cell lung cancer patients.Diagnostic pathology · 2014Article
- Down-regulated miR-22 as predictive biomarkers for prognosis of epithelial ovarian cancer.Diagnostic pathology · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivemiR-132 plays a role in regulating neuronal morphology and cellular excitability. Little is known about the effects of miR-132 in cancer. The aim of this study is to evaluate the expression of miR-132 and its clinical significance in gastric cancer.
methodsCancerous tissues and corresponding normal tissues from 79 patients with gastric cancer were examined for the expression of miR-132 using quantitative PCR and the association between miR-132 expression levels and clinicopathological factors and prognosis was analyzed.
resultsIn 79 clinical samples of gastric cancer patients, miR-132 expression levels in cancer tissues were significantly higher than those in the corresponding normal tissues (P = 0.001). Higher expression levels of miR-132 were associated with more frequent lymph node metastasis (P = 0.033), more lymphatic tumor emboli (P = 0.007), and more advanced stage (P = 0.016). Additionally, expression of miR-132 was an independent prognostic factor for overall survival (P = 0.020).
conclusionmiR-132 could serve as an efficient prognostic factor for gastric cancer patients. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8168577241196050.
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