ArticleDevelopmental medicine and child neurology2014
Risk of cerebral palsy in relation to pregnancy disorders and preterm birth: a national cohort study.
Article in Developmental medicine and child neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04755556 (Effectiveness of Routine Physical Therapy With or Without Home Based Intensive Bimanual Training on Clinical Outcomes in Cerebral Palsy Children), which is not on this map. Cited by 59 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Routine Physical Therapy With or Without Home Based Intensive Bimanual Training on Clinical Outcomes in Cerebral Palsy Children: A Randomized Controlled Trial
Who cites it
59 citing papers in PubMed, 7 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Born at higher risk: persistent male excess risk of cerebral palsy from extreme prematurity to term: a systematic review and meta-analysis.Biology of sex differences · 2026Pooled it
- Global prevalence of long-term neurodevelopmental impairment following extremely preterm birth: a systematic literature review.The Journal of international medical research · 2021Pooled it
- Increasing prevalence of cerebral palsy among children and adolescents in China 1988-2020: A systematic review and meta-analysis.Journal of rehabilitation medicine · 2021Pooled it
- Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review.American journal of perinatology · 2017Pooled it
- Exercise interventions for cerebral palsy.The Cochrane database of systematic reviews · 2017Pooled it
- Chorioamnionitis in the Development of Cerebral Palsy: A Meta-analysis and Systematic Review.Pediatrics · 2017Pooled it
- SGA as a Risk Factor for Cerebral Palsy in Moderate to Late Preterm Infants: a System Review and Meta-analysis.Scientific reports · 2016Pooled it
- Fertility treatment and risk of cerebral palsy: has the association changed in Australia?Human reproduction (Oxford, England) · 2026Article
- Early Diagnoses of Concern Appear Valid in Predicting Adverse Neurodevelopmental Outcomes in Mid-Childhood.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- A sibling study of the prenatal and perinatal risks for cerebral palsy.Pediatric research · 2025Article
- Needs for rehabilitation in China: Estimates based on the Global Burden of Disease Study 1990-2019.Chinese medical journal · 2025Article
- Early-onset preeclampsia/gestational hypertension may be associated with a low incidence of cerebral palsy at 3 years old in singleton very low-birth-weight infants born at 28-31 weeks of gestation (EOPE-DQ study): a multi-center retrospective cohort study in 2013-2016.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Approaching the paradoxical relationship between hypertensive disorders of pregnancy and cerebral palsy among infants born very preterm with very low birth weight.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Inflammation mediated brain damage and cytokine expression in a maternally derived murine model for preterm hypoxic-ischemic encephalopathy.Frontiers in systems biology · 2025Article
- Lower Extremity Musculoskeletal Complications of Spastic Cerebral Palsy.Journal of orthopaedics and sports medicine · 2025Article
- Extrauterine support of pre-term lambs achieves similar transcriptomic profiling to late pre-term lamb brains.Scientific reports · 2024Article
- Cerebral palsy: potential risk factors and functional status among children under three years, a case-control study in northwest Iran.BMC pediatrics · 2024Article
- Childhood growth outcomes 2 years after hypertensive versus normotensive pregnancy: a P4 study.Pediatric research · 2024Article
- Pre-pregnancy and pregnancy disorders, pre-term birth and the risk of cerebral palsy: a population-based study.International journal of epidemiology · 2023Article
- Long-term outcomes of offspring from multiple gestations: a two-sample Mendelian randomization study on multi-system diseases using UK Biobank and FinnGen databases.Journal of translational medicine · 2023Article
Corrections and comments
- Commented on by
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
aimTo assess the risk of developing cerebral palsy in relation to pregnancy disorders and preterm birth.
methodBy linking the Medical Birth Registry of Norway to other national registries, we identified all live births in Norway from 1967 through to 2001. Risks of cerebral palsy (CP) after preterm delivery and pregnancy disorders were estimated in different gestational age groups.
resultIn total, 1 764 509 children delivered at 23 to 43 weeks' gestation were included. The prevalence of CP was 1.8 per 1000 births. Absolute risk of CP was 8.5% among children born at 23 to 27 weeks' gestation, 5.6% at 28 to 30 weeks, 2.0% at 31 to 33 weeks, 0.4% at 34 to 36 weeks, and 0.1% thereafter. Placental abruption, chorioamnionitis, prolonged rupture of membranes, intrauterine growth restriction, pre-eclampsia, multiple births, placenta previa, bleeding, cervical conization, and congenital malformation were all associated with CP. Before 32 weeks' gestation, absolute risk of CP was highest with chorioamnionitis (9.1%) and lowest with pre-eclampsia (3.1%). Among those born after 31 weeks, the absolute risk of CP was more consistently (but also more slightly) increased with a recorded pregnancy disorder.
interpretationEarly delivery and pregnancy disorders were both strong risk factors for CP. The added risks with recorded pregnancy disorders varied within categories of gestational age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.