ArticleEnvironmental health : a global access science source2014
Arsenic exposure, AS3MT polymorphism, and neuropsychological functioning among rural dwelling adults and elders: a cross-sectional study.
Article in Environmental health : a global access science source, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Association of Arsenic Methylation Capacity with Developmental Delays and Health Status in Children: A Prospective Case-Control Trial.Scientific reports · 2016Trial
- Drinking water arsenic, urinary arsenic biomarkers, and cognitive impairment in the REGARDS study.Environmental research · 2026Article
- Arsenic Methyltransferase and Apolipoprotein E Polymorphism in Pregnant Women Exposed to Inorganic Arsenic in Drinking Water in Western Romania.International journal of molecular sciences · 2024Article
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Cortical Synaptic Reorganization Under Chronic Arsenic Exposure.Neurotoxicity research · 2021Article
- A Review of Metal Exposure Studies Conducted in the Rural Southwestern and Mountain West Region of the United States.Current epidemiology reports · 2019Article
- A Review of Environmental Epidemiology Studies in Southwestern and Mountain West Rural Minority Populations.Current epidemiology reports · 2018Article
- Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases.International journal of molecular sciences · 2016Review
- Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis.Reproductive toxicology (Elmsford, N.Y.) · 2016Article
- Article
- CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence.International journal of hypertension · 2015Article
- Arsenic exposure during embryonic development alters the expression of the long noncoding RNA growth arrest specific-5 (Gas5) in a sex-dependent manner.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe aim was to examine the link between low-level arsenic exposure and cognitive functioning, and the potential role of a single nucleotide polymorphism (SNP A35991G, rs10748835) of the AS3MT gene in modifying this link.
methodsData were analyzed on 526 participants from Project FRONTIER. Hierarchical linear regressions were created with neuropsychological raw index scores as the outcome variable and arsenic exposure and AS3MT SNP as different predictor variables.
resultsWithin the total sample, arsenic exposure was negatively associated with language (p < 0.001) and executive functioning (p < 0.001). Among those with the AA genotype of the AS3MT gene, arsenic levels were negatively associated with language (p < 0.001), attention (p = 0.01), and executive functioning (p = 0.04). Among those with the AG genotype, arsenic levels were positively associated with immediate (p = 0.04) and delayed memory (p < 0.001) and negatively associated with executive functioning (p = 0.03). Among those with the GG genotype, arsenic levels were negatively associated with visuospatial functioning (p = 0.02).
conclusionsLow-level arsenic exposure is associated with cognitive functioning; however, this association is modified by an AS3MT gene.
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Registered trials
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