ArticleRedox report : communications in free radical research2014
Serum prolidase enzyme activity and oxidative status in patients with fibromyalgia.
Article in Redox report : communications in free radical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Evaluating Oxidative Stress in Fibromyalgia: Diagnostic Utility and Its Relationship with Clinical and Psychological Parameters.Medicina (Kaunas, Lithuania) · 2025Article
- From imaging techniques to laboratory tests: a multimodal stratification for varicocele-associated decreased semen quality.Basic and clinical andrology · 2025Review
- Management of Fibromyalgia: Novel Nutraceutical Therapies Beyond Traditional Pharmaceuticals.Nutrients · 2025Review
- Metabolomics analysis of plasma samples of patients with fibromyalgia and electromagnetic sensitivity using GC-MS technique.Scientific reports · 2022Article
- The Effects of Balneotherapy on Oxidant/Antioxidant Status in Patients With Fibromyalgia: An Observational Study.Archives of rheumatology · 2020Article
- Article
- A narrative review on the difficulties associated with fibromyalgia diagnosis.Therapeutic advances in musculoskeletal disease · 2018Review
- Evaluation of serum prolidase activity and oxidative stress markers in men with BPH and prostate cancer.BMC urology · 2017Article
- Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia.Archives of rheumatology · 2017Article
- Serum prolidase level in ankylosing spondylitis: low serum levels as a new potential gold standard biomarker for disease activity.Rheumatology international · 2016Article
- Fibromyalgia Pathogenesis and Treatment Options Update.Current pain and headache reports · 2016Review
- Fibromyalgia syndrome in need of effective treatments.The Journal of pharmacology and experimental therapeutics · 2015Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was performed to investigate serum prolidase enzyme activity and oxidative stress in patients diagnosed with fibromyalgia (FM).
methodsThe study population consisted of 40 patients with a previous diagnosis of FM and 30 healthy subjects. We measured serum prolidase enzyme activity, total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and paraoxonase-1 (PON-1) levels.
resultsOn average, FM patients were diagnosed within 3.2 years of symptom onset, and patients had a mean of 14 tender points. There were no significant differences between patients and controls in age, body mass index, serum TAS, or PON-1 levels. However, patients with FM demonstrated higher serum prolidase activity, TOS, and OSI than the control group. Serum prolidase activity was positively correlated with serum TOS, OSI, and visual analog scale pain and fatigue scores. No correlation was found between serum prolidase activity and FM duration or the average number of tender points. DISCUSSION: Our results demonstrate a previously unreported association between serum prolidase enzyme activity and FM. Increased prolidase activity may contribute to the pathogenesis of FM, and measuring serum prolidase enzyme activity may be a useful FM biomarker.
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