ArticleRedox report : communications in free radical research2014
Oxidative stress and ischemia-modified albumin in chronic ischemic heart failure.
Article in Redox report : communications in free radical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Ischemia-modified albumin in rheumatic diseases: A systematic review and meta-analysis.Immunity, inflammation and disease · 2024Pooled it
- Pooled it
- Association between serum uric acid to albumin ratio and all-cause mortality in critically ill patients with sepsis: a retrospective study.BMC infectious diseases · 2025Article
- The Level of Ischemia-Modified Albumin in Healthy Individuals of Different Age Groups.Bulletin of experimental biology and medicine · 2025Article
- Cardiovascular comorbidities are risk factors for increased oxidative stress and DNA damage in migraine patients: a prospective cohort study.Journal of translational medicine · 2025Article
- Determination of SCUBE-1, SCUBE-2, caveolin-1, and ischemia biomarker levels in rats following renal ischemia-reperfusion.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- The assessment of thiol-disulfide homeostasis and ıschemia-modified albumin levels in patients with acromegaly.Pituitary · 2025Article
- Anti-Inflammatory and Antioxidant Effects of White Grape Pomace Polyphenols on Isoproterenol-Induced Myocardial Infarction.International journal of molecular sciences · 2025Article
- Association between red blood cell distribution width-to-albumin ratio and all-cause mortality in intracerebral hemorrhage.Frontiers in nutrition · 2025Article
- The role of ischaemia-modified albumin in the prognosis of acute pancreatitis and its correlation with the NF-The Journal of international medical research · 2024Article
- A systematic review and meta-analysis of ischemia-modified albumin in diabetes mellitus.Heliyon · 2024Article
- Histidine-Bound Dinitrosyl Iron Complexes: Antioxidant and Antiradical Properties.International journal of molecular sciences · 2023Article
- Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis.Redox report : communications in free radical research · 2023Article
- Serum Concentrations of Ischaemia-Modified Albumin in Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Ischemia-Modified Albumin: Origins and Clinical Implications.Disease markers · 2021Review
- Using advanced oxidation protein products and ischaemia-modified albumin to monitor oxidative stress levels in patients with drug-induced liver injury.Scientific reports · 2020Article
- Correlation between ischemia-modified albumin level and coronary collateral circulation.BMC cardiovascular disorders · 2020Article
- Article
- Antioxidant and Anti-Inflammatory Effects of Curcumin Nanoparticles on Drug-Induced Acute Myocardial Infarction in Diabetic Rats.Antioxidants (Basel, Switzerland) · 2019Article
- Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesKnowledge about the role of oxidative stress in human diseases, including cardiovascular system disorders, emphasizes the need for reliable markers of oxidative stress. Here, we evaluated the levels of the novel marker ischemia-modified albumin (IMA), albumin-adjusted IMA (adj-IMA), and the IMA/serum albumin ratio (IMAR) in patients with chronic ischemic heart failure (CIHF).
methodsA total of 55 patients with CIHF and 40 age- and sex-matched healthy individuals were included in the study. Serum levels of IMA, total antioxidant status, and total oxidant status were analyzed, and the adj-IMA level, IMAR, and oxidative stress index were calculated.
resultsSerum IMA, IMAR, total oxidant status levels, and oxidative stress index were significantly higher in patients with CIHF than in the controls (all P < 0.0001), whereas albumin and total antioxidant status levels were significantly lower in the CIHF patients (P < 0.0001 and P = 0.0004, respectively). However, there was no significant difference in serum adj-IMA levels between the groups (P = 0.8). DISCUSSION: We observed impaired oxidant/antioxidant status in favor of oxidative stress in CIHF patients. Oxidative stress may be a key factor in the development of hypoalbuminemia in CIHF. Further studies are needed to establish the relationships among IMA, albumin, and redox balance in CIHF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.