ReviewAddiction biology2015
Dorsal medial prefrontal cortex (MPFC) circuitry in rodent models of cocaine use: implications for drug addiction therapies.
Review in Addiction biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 59 citations in OpenAlex.
- Neural Response to Theta-Burst Stimulation Predicts Long-Term Relapse in Patients With Alcohol Use Disorder: A Pilot fMRI Study.Addiction biology · 2026Trial
- Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: A pilot study.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Trial
- Article
- Sex-specific Alterations in the mRNA Expression of Histone Deacetylases (HDACs) in the Rat Brain Following Prolonged Abstinence from Methamphetamine Self-administration.Molecular neurobiology · 2025Article
- The functional connectivity between the dorsolateral prefrontal cortex and the medial prefrontal cortex underlying the association between self-control and delay discounting.Brain structure & function · 2025Article
- Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats.Frontiers in pharmacology · 2025Article
- Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder.The American journal of drug and alcohol abuse · 2024Article
- Intrinsic Functional Connectivity between the Anterior Insular and Retrosplenial Cortex as a Moderator and Consequence of Cocaine Self-Administration in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Medial prefrontal cortex suppresses reward-seeking behavior with risk of punishment by reducing sensitivity to reward.Frontiers in neuroscience · 2024Article
- Cell-Type-Specific Neuroproteomics of Synapses.Biomolecules · 2023Review
- Sex differences in chronic pain-induced mental disorders: Mechanisms of cerebral circuitry.Frontiers in molecular neuroscience · 2023Review
- Functional networks in prolonged disorders of consciousness.Frontiers in neuroscience · 2023Review
- Sex differences in the medial prefrontal cortical glutamate system.Biology of sex differences · 2022Article
- Differential expression of miR-1249-3p and miR-34b-5p between vulnerable and resilient phenotypes of cocaine addiction.Addiction biology · 2022Article
- Sex-Specific Alterations in Dopamine Metabolism in the Brain after Methamphetamine Self-Administration.International journal of molecular sciences · 2022Article
- Does Traumatic Brain Injury Cause Risky Substance Use or Substance Use Disorder?Biological psychiatry · 2022Review
- Transcranial Magnetic Stimulation for the Treatment of Cocaine Addiction: A Systematic Review.Journal of clinical medicine · 2021Review
- Neurophysiological correlate of incubation of craving in individuals with methamphetamine use disorder.Molecular psychiatry · 2021Article
- Customizing MRI-Compatible Multifunctional Neural Interfaces through Fiber Drawing.Advanced functional materials · 2021Article
- Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1 +/- mice.Translational psychiatry · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Although the importance of the medial prefrontal cortex (MPFC) in cocaine addiction is well established, its precise contribution to cocaine seeking, taking and relapse remains incompletely understood. In particular, across two different models of cocaine self-administration, pharmacological or optogenetic activation of the dorsal MPFC has been reported to sometimes promote and sometimes inhibit cocaine seeking. We highlight important methodological differences between the two experimental paradigms and propose a framework to potentially reconcile the apparent discrepancy. We also draw parallels between these pre-clinical models of cocaine self-administration and human neuro-imaging studies in cocaine users, and argue that both lines of evidence point to dynamic interactions between cue-reactivity processes and control processes within the dorsal MPFC circuitry. From a translational perspective, these findings underscore the importance of interventions and therapeutics targeting not just a brain region, but a specific computational process within that brain region, and may have implications for the design and implementation of more effective treatments for human cocaine addiction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.