ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2014
Number of P-wave fragmentations on P-SAECG correlates with infiltrated atrial fat.
Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Clinically-aligned explainable AI for atrial fibrillation detection: A U-Net inspired multi-lead ECG analysis framework.Computer methods and programs in biomedicine · 2026Article
- Patients with persistent atrial fibrillation and metabolic comorbidities have an altered inflammatory state of atrial epicardial adipose tissue, which is linked to CT-attenuation.Cardiovascular diabetology · 2025Article
- Relation between the Epicardial Fat Thickness and the Cardiac Conduction System in Children and Adolescents with Diabetes.Hormone research in paediatrics · 2024Article
- Impact of Obesity on Atrial Electrophysiological Substrate.Journal of cardiovascular development and disease · 2023Review
- Article
- Assessing Atrial Fibrillation Substrates by P Wave Analysis: A Comprehensive Review.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020Review
- Association of Abdominal Adiposity with Cardiovascular Mortality in Incident Hemodialysis.American journal of nephrology · 2018Article
- Observational
- Electrocardiographic deep terminal negativity of the P wave in V(1) and risk of sudden cardiac death: the Atherosclerosis Risk in Communities (ARIC) study.Journal of the American Heart Association · 2014Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundAlthough atrial fibrillation (AF) triggers are known, the underlying AF substrate is less well understood. The goal of our study was to explore correlations between electrophysiological and structural characteristics of atria in patients with paroxysmal AF and individuals at AF risk.
methodsPatients in sinus rhythm (N = 90; age 57 ± 10 year; 55 men [63.2%]) with structural heart disease and paroxysmal AF (n = 12 [13%]), or with AF risk factors and LVEF > 35% (n = 78), underwent SAECG and cardiac magnetic resonance study. Interatrial and epicardial fat was analyzed with a Dark-blood DIR-prepared Fat-Water-separated sequence in the horizontal longitudinal axis. All local P-wave extrema were identified on SAECG leads during sinus rhythm. A P-wave fragmentation (Pf) was defined as an absolute difference between adjacent extrema which was above three standard deviations of noise, and was normalized by the duration of the P wave in the corresponding lead.
resultsThe Pf was greater on the filtered than on the unfiltered P-SAECG signal (13.1 ± 3.8 vs. 3.4 ± 1.2; P < 0.0001). Pf was the greatest on the Y lead (13.0 ± 3.5 on Y lead vs. 12.1 ± 3.4 on Z lead; P = 0.003. Pf on Z lead correlated with interatrial fat index (r = 0.544; P = 0.001). Epicardial fat significantly correlated with body mass index (BMI; r = 0.302; P = 0.015). After adjustment for BMI, left atrium (LA) size, epicardial fat, and interatrial septum width, interatrial fat independently associated with the Pf on Z lead (β-coefficient 0.009 [95%CI 0.0003-0.019]; P = 0.043).
conclusionsInfiltrated atrial fat correlates with discontinuous conduction on posterior LA wall and represents AF early substrate.
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