ArticlePathology oncology research : POR2014
Adiponectin receptor expression predicts favorable prognosis in cases of hepatocellular carcinoma.
Article in Pathology oncology research : POR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Pooled it
- Adiponectin is associated with poor prognosis in carcinoma patients: evidence from a meta-analysis.Lipids in health and disease · 2015Pooled it
- Serum adiponectin levels may be associated with the pathogenesis of hepatocellular carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- Tumor Necrosis Factor-Alpha and Adiponectin in Nonalcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma.Cancers · 2023Review
- Data on Adiponectin from 2010 to 2020: Therapeutic Target and Prognostic Factor for Liver Diseases?International journal of molecular sciences · 2020Review
- The Possible Role of Adipokines in HCV Associated Hepatocellular Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Histopathological characteristics of needle core biopsy and surgical specimens from patients with solitary hepatocellular carcinoma or intrahepatic cholangiocarcinoma.World journal of gastrointestinal oncology · 2019Article
- Article
- Adiponectin receptor agonists inhibit leptin induced pSTAT3 andOncotarget · 2017Article
- Expression of Adiponectin Receptor-1 and Prognosis of Epithelial Ovarian Cancer Patients.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Analysis of circulating adipokines in patients newly diagnosed with solid cancer: Associations with measures of adiposity and tumor characteristics.Oncology letters · 2017Article
- Liver resection associated with better outcomes for single large hepatocellular carcinoma located in the same section.Medicine · 2017Observational
- Plasma Adiponectin and Hepatocellular Carcinoma Survival Among Patients Without Liver Transplantation.Anticancer research · 2016Article
- Evolving role of adiponectin in cancer-controversies and update.Cancer biology & medicine · 2016Article
- Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma.Gastroenterology · 2015Article
- Diagnostic Value of Preoperative Needle Biopsy for Tumor Grading Assessment in Hepatocellular Carcinoma.PloS one · 2015Article
- A novel prognostic factor for hepatocellular carcinoma: protein disulfide isomerase.The Korean journal of internal medicine · 2014Article
- Screening of Prognostic Biomarkers for Stereotactic Body Radiation Therapy in Primary Liver Cancer.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity influences risk, progression and prognosis of various cancers including hepatocellular carcinoma (HCC). Adipose-tissue-derived adipokines has been considered to be involved in tumorigenesis and adiponecin, one such adipokine, has antiproliferative effect on obesity-related malignancies, though variable signal pathway mediated by adiponectin receptors-AdipoR1 and AdipoR2. In this study, we investigated expression of adiponectin and adiponectin receptors in tumor and non-tumorous hepatic tissues of HCC patients and its clinicopathological significance. We collected 75 HCC tissues and 70 non-tumorous hepatic tissues from HCC patients who underwent surgical resection. The tissue microarrays were constructed and immunohistochemical study for adiponectin, AdipoR1 and AipoR2 was performed. Adiponectin and AdipoR1 expression rates were significantly lower in HCC than non-neoplastic hepatic tissues (82.7 % vs. 97.1 % and 24.0 % vs. 90 %, P = 0.005 and <0.001, respectively). Immunopositivity for adiponectin was associated with small tumor size, low Edmonson-Steiner grade and absence of other organ invasion (P = 0.015, 0.021 and 0.028, respectively). AdipoR1 expression had association with absence of vascular invasion (P = 0.028) and AdipoR2 expression was correlated with lower histologic grade and low pathologic T-stage (P = 0.003 and 0.008, respectively). Cox regression analysis revealed that low expression of AdipoR1 and AdipoR2 were associated with increased risk of recurrence and death, respectively (hazard ration = 3.222 and 14.797, respectively). These findings suggest that loss of adiponectin, and adiponectin receptors expression is associated with aggressive clinicopathological features of HCC and AdipoR1 and AdipoR2 might serve as the independent prognostic factors for HCC patients.
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