ArticleCanadian journal of gastroenterology & hepatology2014
The feasibility and reliability of transient elastography using Fibroscan®: a practice audit of 2335 examinations.
Article in Canadian journal of gastroenterology & hepatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- A Handheld Probe for Focused Shear Wave Transient Elastography.Annals of biomedical engineering · 2026Article
- An Alternative Non-Invasive Screening Model for Liver Fibrosis among US Adults at Risk of MASLD.Diseases (Basel, Switzerland) · 2024Article
- Determining the ideal measurement site and respiratory condition for liver transient elastography: toward clinical practice standardization.Insights into imaging · 2024Article
- Article
- Palm-Sized Wireless Transient Elastography System with Real-Time B-Mode Ultrasound Imaging Guidance: Toward Point-of-Care Liver Fibrosis Assessment.Diagnostics (Basel, Switzerland) · 2024Article
- Advances in Noninvasive Molecular Imaging Probes for Liver Fibrosis Diagnosis.Biomaterials research · 2024Review
- Evaluation of the Feasibility of 2D-SWE to Measure Liver Stiffness in Healthy Dogs and Analysis of Possible Confounding Factors.Animals : an open access journal from MDPI · 2023Article
- Two-dimensional shear wave elastography utilized in patients with ascites: a more reliable method than transient elastography for noninvasively detecting the liver stiffness-an original study with 170 patients.Annals of translational medicine · 2023Article
- Prevalence and predictors of abnormal alanine aminotransferase in patients with HCV who have achieved SVR.Journal of viral hepatitis · 2023Article
- Assessing Interactions betweenInternational journal of environmental research and public health · 2021Article
- Noninvasive Assessment of Hepatitis C Virus Infected Patients Using Vibration-Controlled Transient Elastography.Journal of clinical medicine · 2021Review
- Comparative analysis of metabolic risk factors for progression of non-alcoholic fatty liver disease.Clinical and experimental hepatology · 2021Article
- Spectrum of liver diseases in patients referred for Fibroscan: A single center experience in the Middle East.Annals of medicine and surgery (2012) · 2020Article
- Technical success rates and reliability of spin-echo echo-planar imaging (SE-EPI) MR elastography in patients with chronic liver disease or liver cirrhosis.European radiology · 2020Article
- Quantitative Evaluation of Liver Fibrosis on T1 Relaxometry in Comparison with Fibroscan.Taehan Yongsang Uihakhoe chi · 2020Article
- Learning curve of liver stiffness measurement using a new hybrid machine composed of transient elastography interfaced with ultrasound.European radiology · 2020Article
- Optimal liver stiffness measurement values for the diagnosis of significant fibrosis and cirrhosis in chronic liver disease in Singapore.Singapore medical journal · 2019Article
- Transient elastography reliably estimates liver fibrosis in autoimmune hepatitis.Clinical and experimental hepatology · 2019Article
- Usefulness of Transient Elastography for Non-Invasive Diagnosis of Liver Fibrosis in Pediatric Non-Alcoholic Steatohepatitis.Journal of Korean medical science · 2019Article
- Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease.Hepatology (Baltimore, Md.) · 2018Article
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11 authors.
Funding
Abstract
backgroundLiver stiffness measurement (LSM) using transient elastography is widely used in the management of patients with chronic liver disease.
objectivesTo examine the feasibility and reliability of LSM, and to identify patient and operator characteristics predictive of poorly reliable results.
methodsThe present retrospective study investigated the frequency and determinants of poorly reliable LSM (interquartile range [IQR]⁄median LSM [IQR⁄M] >30% with median liver stiffness ≥7.1 kPa) using the FibroScan (Echosens, France) over a three-year period. Two experienced operators performed all LSMs. Multiple logistic regression analyses examined potential predictors of poorly reliable LSMs including age, sex, liver disease, the operator, operator experience (<500 versus ≥500 scans), FibroScan probe (M versus XL), comorbidities and liver stiffness. In a subset of patients, medical records were reviewed to identify obesity (body mass index ≥30 kg⁄m2).
resultsBetween July 2008 and June 2011, 2335 patients with liver disease underwent LSM (86% using the M probe). LSM failure (no valid measurements) occurred in 1.6% (n=37) and was more common using the XL than the M probe (3.4% versus 1.3%; P=0.01). Excluding LSM failures, poorly reliable LSMs were observed in 4.9% (n=113) of patients. Independent predictors of poorly reliable LSM included older age (OR 1.03 [95% CI 1.01 to 1.05]), chronic pulmonary disease (OR 1.58 [95% CI 1.05 to 2.37), coagulopathy (OR 2.22 [95% CI 1.31 to 3.76) and higher liver stiffness (OR per kPa 1.03 [95% CI 1.02 to 1.05]), including presumed cirrhosis (stiffness ≥12.5 kPa; OR 5.24 [95% CI 3.49 to 7.89]). Sex, diabetes, the underlying liver disease and FibroScan probe were not significant. Although reliability varied according to operator (P<0.0005), operator experience was not significant. In a subanalysis including 434 patients with body mass index data, obesity influenced the rate of poorly reliable results (OR 2.93 [95% CI 0.95 to 9.05]; P=0.06).
conclusionsFibroScan failure and poorly reliable LSM are uncommon. The most important determinants of poorly reliable results are older age, obesity, higher liver stiffness and the operator, the latter emphasizing the need for adequate training.
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