ArticleJournal of mass spectrometry : JMS2014
Multiple-stage linear ion-trap with high resolution mass spectrometry towards complete structural characterization of phosphatidylethanolamines containing cyclopropane fatty acyl chain in Leishmania infantum.
Article in Journal of mass spectrometry : JMS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Chemical Profiling of Polar Lipids and the Polyphenolic Fraction of Commercial ItalianBiomolecules · 2024Article
- Fatty Acid Composition and Metabolism inInternational journal of molecular sciences · 2023Review
- Fatty Acid Profiles ofPathogens (Basel, Switzerland) · 2022Article
- The lipidome ofFrontiers in cellular and infection microbiology · 2022Article
- Mapping metabolome changes inJournal of advanced research · 2021Review
- CEPT1-Mediated Phospholipogenesis Regulates Endothelial Cell Function and Ischemia-Induced Angiogenesis Through PPARα.Diabetes · 2021Article
- Shotgun Lipidomic Analysis of Leishmania Cells.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Article
- Unsaturation Elements and Other Modifications of Phospholipids in Bacteria: New Insight from Ultraviolet Photodissociation Mass Spectrometry.Analytical chemistry · 2020Article
- Localization of Cyclopropane Modifications in Bacterial Lipids via 213 nm Ultraviolet Photodissociation Mass Spectrometry.Analytical chemistry · 2019Article
- Mass spectrometry-based shotgun lipidomics - a critical review from the technical point of view.Analytical and bioanalytical chemistry · 2018Review
- Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques.Journal of lipid research · 2018Article
- Cyclopropane fatty acid synthesis affects cell shape and acid resistance in Leishmania mexicana.International journal for parasitology · 2018Article
- Lipidomics and anti-trypanosomatid chemotherapy.Clinical and translational medicine · 2017Review
- Ozone-induced dissociation on a traveling wave high-resolution mass spectrometer for determination of double-bond position in lipids.Rapid communications in mass spectrometry : RCM · 2017Article
- Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms.PLoS neglected tropical diseases · 2016Article
- Plasmenylethanolamine synthesis in Leishmania major.Molecular microbiology · 2016Article
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Authors and funding
4 authors.
Funding
Abstract
The structures of phosphatidylethanolamine (PE) in Leishmania infantum are unique in that they consist of a rare cyclopropane fatty acid (CFA) containing PE subfamily, including CFA-containing plasmalogen PE species. In this contribution, we applied multiple-stage linear ion-trap combined with high-resolution mass spectrometry to define the structures of PEs that were desorbed as [M - H](-) and [M - H + 2Li](+) ions by ESI, respectively. The structural information arising from MS(n) on both the molecular species are complimentary, permitting complete determination of PE structures, including the identities of the fatty acid substituents and their location on the glycerol backbone, more importantly, the positions of the double bond(s) and of the cyclopropane chain of the fatty acid chain, directing to the realization of the CFA biosynthesis pathways that were reported previously. We also uncovered the presence of a minor dimethyl-PE subclass that has not been previously reported in L. infantum. This LIT MS(n) mass spectrometric approach led to unambiguous identification of PE molecules including many isomers in complex mixture that would otherwise be very difficult to define using other analytical approaches.
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