ArticleThe Journal of cell biology1988
Modulation of cellular morphology and locomotory activity by antibodies against myosin.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 86 citations in OpenAlex.
- R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing.Tissue barriers · 2019Article
- Myosin IIB deficiency in embryonic fibroblasts affects regulators and core members of the par polarity complex.Histochemistry and cell biology · 2011Article
- Nonmuscle myosin II is responsible for maintaining endothelial cell basal tone and stress fiber integrity.American journal of physiology. Cell physiology · 2008Article
- Two regions of the tail are necessary for the isoform-specific functions of nonmuscle myosin IIB.Molecular biology of the cell · 2007Article
- The role of myosin II motor activity in distributing myosin asymmetrically and coupling protrusive activity to cell translocation.Molecular biology of the cell · 2006Article
- Calcium-responsive contractility during fertilization in sea urchin eggs.Developmental dynamics : an official publication of the American Association of Anatomists · 2006Article
- Article
- Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions.Molecular biology of the cell · 1999Article
- Polymerizing microtubules activate site-directed F-actin assembly in nerve growth cones.Molecular biology of the cell · 1999Article
- Signaling pathways underlying eosinophil cell motility revealed by using caged peptides.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.The Journal of cell biology · 1996Article
- A fluorescent protein biosensor of myosin II regulatory light chain phosphorylation reports a gradient of phosphorylated myosin II in migrating cells.Molecular biology of the cell · 1995Article
- Myosin II filament assemblies in the active lamella of fibroblasts: their morphogenesis and role in the formation of actin filament bundles.The Journal of cell biology · 1995Article
- Non-sarcomeric mode of myosin II organization in the fibroblast lamellum.The Journal of cell biology · 1993Article
- In vitro models of tail contraction and cytoplasmic streaming in amoeboid cells.The Journal of cell biology · 1993Article
- Gradients in the concentration and assembly of myosin II in living fibroblasts during locomotion and fiber transport.Molecular biology of the cell · 1993Article
- Relative distribution of actin, myosin I, and myosin II during the wound healing response of fibroblasts.The Journal of cell biology · 1993Article
- Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.Molecular and cellular biology · 1993Article
- Autocrine motility factor and its receptor: role in cell locomotion and metastasis.Cancer metastasis reviews · 1992Review
- The distribution of myosin II in Dictyostelium discoideum slug cells.The Journal of cell biology · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three monoclonal antibodies directed against chicken brush border myosin were used to study the possible function of myosin in microfilament organization and locomotion of chicken fibroblasts. These antibodies bind to distinct and separate epitopes on the heavy chain of chicken nonmuscle myosin and display differential effects of myosin filament formation and actin-myosin interaction (Citi, S., and J. Kendrick-Jones. 1988. J. Musc. Res. Cell Motil. 9: 306-319). When injected into chicken fibroblasts, all antibodies induced breakdown of stress fibers. Concomitantly, a large proportion of the cells developed extensive lamellae which altered their morphology drastically. These cells showed also increased locomotory activity. All effects were concentration dependent and reversible. The most drastic alterations were observed with cells injected with antibody quantities exceeding the quantity of cellular myosin (molar ratios of antibody to myosin greater than 3:1). The finding that antibodies with different effects on myosin filament formation in vitro all induce similar intracellular processes suggests that it is the antibody-induced decrease in functional myosin that triggers an increase in plasma membrane dynamics and locomotory activity, rather than differences in myosin filament length or conformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.