ArticleMarine drugs2014
Anti-inflammatory potential of monogalactosyl diacylglycerols and a monoacylglycerol from the edible brown seaweed Fucus spiralis Linnaeus.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 71 citations in OpenAlex.
- Algae-Derived Bioactive Compounds as Platforms for Translational Biotechnology and Health Applications.Biotech (Basel (Switzerland)) · 2026Review
- Elucidating a novel metabolic pathway for enhanced antimicrobial glycolipid biosurfactant production in the yeast Meyerozyma guilliermondii.Scientific reports · 2025Article
- Article
- Extraction, Isolation and Biological Activity of Two Glycolipids fromMarine drugs · 2024Article
- Seasonal Monitoring of Volatiles and Antioxidant Activity of Brown AlgaMarine drugs · 2023Article
- Shared Genes ofInternational journal of molecular sciences · 2023Article
- Seaweed Derived Lipids Are a Potential Anti-Inflammatory Agent: A Review.International journal of environmental research and public health · 2022Review
- Glyceroglycolipids in marine algae: A review of their pharmacological activity.Frontiers in pharmacology · 2022Review
- Virucidal effect of monogalactosyl diacylglyceride from a green microalga, Coccomyxa sp. KJ, against clinical isolates of SARS-CoV-2 as assessed by a plaque assay.Journal of clinical laboratory analysis · 2022Article
- Polar lipidomic profile shows Chlorococcum amblystomatis as a promising source of value-added lipids.Scientific reports · 2021Article
- Neutral Lipids, Glycolipids, and Phospholipids, Isolated from Sandfish (Marine drugs · 2020Article
- Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications.Molecules (Basel, Switzerland) · 2020Article
- Highlighting the Biological Potential of the Brown SeaweedAntioxidants (Basel, Switzerland) · 2020Article
- Nutrient availability affects the polar lipidome of Halimione portulacoides leaves cultured in hydroponics.Scientific reports · 2020Article
- Metabolomic Insights into Marine Phytoplankton Diversity.Marine drugs · 2020Article
- Lipidomic Signatures Reveal Seasonal Shifts on the Relative Abundance of High-Valued Lipids from the Brown AlgaeMarine drugs · 2019Article
- Article
- Therapeutic Applications of Rose Hips from Different Rosa Species.International journal of molecular sciences · 2017Review
- Valorization of Lipids from Gracilaria sp. through Lipidomics and Decoding of Antiproliferative and Anti-Inflammatory Activity.Marine drugs · 2017Article
- Bioprospecting of Marine Macrophytes Using MS-Based Lipidomics as a New Approach.Marine drugs · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A monoacylglycerol (1) and a 1:1 mixture of two monogalactosyl diacylglycerols (MGDGs) (2 and 3) were isolated from the brown seaweed Fucus spiralis Linnaeus. The structures were elucidated by spectroscopic means (NMR and MS) and by comparison with the literature. Compound 1 was composed of a glycerol moiety linked to oleic acid (C18:1 Ω9). Compounds 2 and 3 contained a glycerol moiety linked to a galactose unit and eicosapentaenoic acid (C20:5 Ω3) combined with octadecatetraenoic acid (C18:4 Ω3) or linolenic acid (C18:3 Ω3), respectively. The isolated compounds were tested for their cytotoxic and anti-inflammatory activity in RAW 264.7 macrophage cells. All of them inhibited NO production at non-cytotoxic concentrations. The fraction consisting of compounds 2 and 3, in a ratio of 1:1, was slightly more effective than compound 1 (IC₅₀ of 60.06 and 65.70 µg/mL, respectively). To our knowledge, this is the first report of these compounds from F. spiralis and on their anti-inflammatory capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.