ArticleHeredity2014
Inbreeding within human Schistosoma mansoni: do host-specific factors shape the genetic composition of parasite populations?
Article in Heredity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Schistosomiasis Interventions in Africa: Assessment and Systematic Review.Journal of parasitology research · 2025Review
- The Truman Show for Human Helminthic Parasites: A Review of Recent Advances in In Vitro Cultivation Platforms.Microorganisms · 2023Review
- A genome sequence for Biomphalaria pfeifferi, the major vector snail for the human-infecting parasite Schistosoma mansoni.PLoS neglected tropical diseases · 2023Article
- High levels of inbreeding with spatial and host-associated structure in lice of an endangered freshwater seal.Molecular ecology · 2022Article
- Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni.Molecular ecology · 2022Article
- Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration.Nature communications · 2021Article
- Schistosomiasis Morbidity Hotspots: Roles of the Human Host, the Parasite and Their Interface in the Development of Severe Morbidity.Frontiers in immunology · 2021Review
- Genetic evidence for the role of non-human primates as reservoir hosts for human schistosomiasis.PLoS neglected tropical diseases · 2020Article
- Impacts of host gender on Schistosoma mansoni risk in rural Uganda-A mixed-methods approach.PLoS neglected tropical diseases · 2020Article
- Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda.Parasites & vectors · 2019Article
- Estimating helminth burdens using sibship reconstruction.Parasites & vectors · 2019Article
- Population Structure and Dynamics of Helminthic Infection: Schistosomiasis.Microbiology spectrum · 2019Review
- The effect of sample size on estimates of genetic differentiation and effective population size for Schistosoma mansoni populations.International journal for parasitology · 2018Article
- Genetic diversity, multiplicity of infection and population structure of Schistosoma mansoni isolates from human hosts in Ethiopia.BMC genetics · 2015Article
- Reconstructing Colonization Dynamics of the Human Parasite Schistosoma mansoni following Anthropogenic Environmental Changes in Northwest Senegal.PLoS neglected tropical diseases · 2015Article
- Genetic diversity among natural populations ofJournal of microscopy and ultrastructureArticle
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The size, structure and distribution of host populations are key determinants of the genetic composition of parasite populations. Despite the evolutionary and epidemiological merits, there has been little consideration of how host heterogeneities affect the evolutionary trajectories of parasite populations. We assessed the genetic composition of natural populations of the parasite Schistosoma mansoni in northern Senegal. A total of 1346 parasites were collected from 14 snail and 57 human hosts within three villages and individually genotyped using nine microsatellite markers. Human host demographic parameters (age, gender and village of residence) and co-infection with Schistosoma haematobium were documented, and S. mansoni infection intensities were quantified. F-statistics and clustering analyses revealed a random distribution (panmixia) of parasite genetic variation among villages and hosts, confirming the concept of human hosts as 'genetic mixing bowls' for schistosomes. Host gender and village of residence did not show any association with parasite genetics. Host age, however, was significantly correlated with parasite inbreeding and heterozygosity, with children being more infected by related parasites than adults. The patterns may be explained by (1) genotype-dependent 'concomitant immunity' that leads to selective recruitment of genetically unrelated worms with host age, and/or (2) the 'genetic mixing bowl' hypothesis, where older hosts have been exposed to a wider variety of parasite strains than children. The present study suggests that host-specific factors may shape the genetic composition of schistosome populations, revealing important insights into host-parasite interactions within a natural system.
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