ArticleLasers in medical science2014
The effects of low-level diode laser irradiation on differentiation, antigenic profile, and phagocytic capacity of osteoblast-like cells (MG-63).
Article in Lasers in medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The effectiveness of photobiomodulation therapy on bone regeneration of oral and craniofacial defects. A systematic review of animal, and in-vitro studies.Lasers in medical science · 2025Pooled it
- Low-level laser therapy with 940 nm diode laser on stability of dental implants: a randomized controlled clinical trial.Lasers in medical science · 2018Trial
- Effects of photobiomodulation on different phases of in vitro osteogenesis.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- Photobiomodulation Therapy Affects the Elastic Modulus, Cytoskeletal Rearrangement and Migration Capability of Human Osteosarcoma Cells.Lasers in medical science · 2022Article
- In vivo efficacy of low-level laser therapy on bone regeneration.Lasers in medical science · 2022Article
- Effects of Two Protocols of Low-Level Laser Therapy on the Proliferation and Differentiation of Human Dental Pulp Stem Cells on Sandblasted Titanium Discs: AnJournal of lasers in medical sciences · 2022Article
- Human adipose tissue-derived mesenchymal stromal cells and their phagocytic capacity.Journal of cellular and molecular medicine · 2022Article
- Photobiomodulation by Near-Infrared 980-nm Wavelengths Regulates Pre-Osteoblast Proliferation and Viability through the PI3K/Akt/Bcl-2 Pathway.International journal of molecular sciences · 2021Article
- Laser and LED photobiomodulation effects in osteogenic or regular medium on rat calvaria osteoblasts obtained by newly forming bone technique.Lasers in medical science · 2021Article
- Effect of different low-level intensity laser therapy (LLLT) irradiation protocols on the osseointegration of implants placed in grafted areas.Journal of applied oral science : revista FOB · 2021Article
- In Vitro Cytological Responses against Laser Photobiomodulation for Periodontal Regeneration.International journal of molecular sciences · 2020Review
- Review
- Human Fibroblast Gene Expression Modulation Using 940 NM Diode Laser.Scientific reports · 2019Article
- Indocyanine green-mediated photobiomodulation on human osteoblast cells.Lasers in medical science · 2018Article
- Cultured Human Fibroblast Biostimulation Using a 940 nm Diode Laser.Materials (Basel, Switzerland) · 2017Article
- Biostimulation with diode laser positively regulates cementoblast functions, in vitro.Lasers in medical science · 2017Article
- Effects of low-level laser therapy on the expression of osteogenic genes during the initial stages of bone healing in rats: a microarray analysis.Lasers in medical science · 2015Article
- Low-level laser irradiation promotes the proliferation and maturation of keratinocytes during epithelial wound repair.Journal of biophotonics · 2015Article
- The influence of laser radiation on human osteoblasts cultured on nanostructured composite substrates.Clujul medical (1957) · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous in vivo and in vitro studies have reported that low-level diode laser therapy induces a biostimulatory effect, such as cell proliferation. The aim of the present study was to evaluate whether the laser irradiation of osteoblast-like cells (MG-63) can modify alkaline phosphatase activity (ALP), antigenic profile, and phagocytic capacity. The MG-63 cell line was exposed to diode laser (ezLase) of 940 nm at 1-1.5 W/cm(2) and 3-4 J. ALP was evaluated by a spectrophotometric technique and antigenic expression analysis (CD 54, CD80, CD86, HLA-DR), and phagocytic activity was analyzed by flow cytometry. At 24 h, the treated groups showed an increased ALP, and the highest increase versus controls (P = 0.002) was at the dose of 1 W/cm(2) and 3 J; this modulation of the antigenic profile translated into a reduced expression of CD54, CD86, and HLA-DR and a slightly decreased phagocytic capacity with respect to the nonirradiated control group at the different intensities and fluencies assayed. These results demonstrate that laser therapy can exert a biostimulatory effect on osteoblastic cells at different levels, which may be clinically useful in the regeneration of bone tissue.
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